Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.2.22 extracted from

  • Mansouri, S.; Nourollahzadeh, E.; Hudak, K.A.
    Pokeweed antiviral protein depurinates the sarcin/ricin loop of the rRNA prior to binding of aminoacyl-tRNA to the ribosomal A-site (2006), RNA, 12, 1683-1692.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Saccharomyces cerevisiae strain mak8-1 which is more resistant to the enzyme in vivo due to higher affinity for aminoacyl-tRNA Phytolacca americana

Inhibitors

Inhibitors Comment Organism Structure
puromycin prior incubation of ribosomes with puromycin inhibits both the binding and depurination by the enzyme Phytolacca americana

Organism

Organism UniProt Comment Textmining
Phytolacca americana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
25S rNA + H2O
-
Phytolacca americana ? enzyme depurinates the sarcin/ricin loop when the A-site of the ribosomal peptidyl-transferase center is unoccupied ?