Application | Comment | Organism |
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medicine | treatment with dimethylsulfoxide and lipopolyamine administration both generate substantial cellular sensitization to ricin and a chemical conjugate of urokinase plasminogen activator and saporin used as anticancer toxin. Major site for the dimethylsulfoxide-facilitated entry of saporin into the cytosol is an endosomal trafficking step preceeding cargo delivery to the late endosome. Senitization effects are specific for saporin and suggest a translocation of saporin via endosomal disruption | Saponaria officinalis |
Organism | UniProt | Comment | Textmining |
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Saponaria officinalis | - |
- |
- |