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Literature summary for 3.2.2.22 extracted from

  • Geden, S.E.; Gardner, R.A.; Fabbrini, M.S.; Ohashi, M.; Phanstiel Iv, O.; Teter, K.
    Lipopolyamine treatment increases the efficacy of intoxication with saporin and an anticancer saporin conjugate (2007), FEBS J., 274, 4825-4836.
    View publication on PubMed

Application

Application Comment Organism
medicine treatment with dimethylsulfoxide and lipopolyamine administration both generate substantial cellular sensitization to ricin and a chemical conjugate of urokinase plasminogen activator and saporin used as anticancer toxin. Major site for the dimethylsulfoxide-facilitated entry of saporin into the cytosol is an endosomal trafficking step preceeding cargo delivery to the late endosome. Senitization effects are specific for saporin and suggest a translocation of saporin via endosomal disruption Saponaria officinalis

Organism

Organism UniProt Comment Textmining
Saponaria officinalis
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