Literature summary for 3.2.2.22 extracted from

Bachran, C.; Sutherland, M.; Heisler, I.; Hebestreit, P.; Melzig, M.F.; Fuchs, H.
The saponin-mediated enhanced uptake of targeted saporin-based drugs is strongly dependent on the saponin structure (2006), Exp. Biol. Med., 231, 412-420.

Search for more literature for 3.2.2.22

Application

Application	Comment	Organism
medicine	construction of chimeric toxin composed of saporin, a cleavable adapter, and human epidermic growth factor. Presence of the saponins saponinum album or quillajasaponin enhances cytotoxicity of the construct more than 1000fold and decreases IC50 values from 2.4 nM in absence of saponin to 0.18 pM in presence of saponinum album. Quillajasaponin enhances the cytotoxicity both on control cells lacking epidermal growth factor receptor and on target cells, while saponinum album is target cell receptor specific	Saponaria officinalis

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of chimeric toxin composed of saporin, a cleavable adapter, and human epidermic growth factor. Presence of the saponins saponinum album or quillajasaponin enhances cytotoxicity of the construct more than 1000fold and decreases IC50 values from 2.4 nM in absence of saponin to 0.18 pM in presence of saponinum album. Quillajasaponin enhances the cytotoxicity both on control cells lacking epidermal growth factor receptor and on target cells, while saponinum album is target cell receptor specific	Saponaria officinalis

Organism

Organism	UniProt	Comment	Textmining
Saponaria officinalis	-	-	-

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Release 2023.1 (January 2023)