Crystallization (Comment) | Organism |
---|---|
the smallest ligand stabilizing an open conformer of the ricin A chain active site pocket is an amide group, bound weakly by only a few hydrogen bonds to the protein. Complexes with small amide-containing molecules also reveal a switch in geometry from a parallel towards a splayed arrangement of an arginine-tryptophan cation-pi interaction that was associated with an increase and redshift in tryptophan fluorescence upon ligand binding. Urea binding has a favorable enthalpy change and unfavorable entropy change. The side-chain position of residue >80 in a complex with adenine suggests a smaller role for aromatic stacking at the ricin active site | Ricinus communis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ricinus communis | P02879 | ricin A chain | - |