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Literature summary for 3.2.2.22 extracted from

  • Wang, B.Z.; Zou, W.G.; Liu, W.Y.; Liu, X.Y.
    The lower cytotoxicity of cinnamomin (a type II RIP) is due to its B-chain (2006), Arch. Biochem. Biophys., 451, 91-96.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information construction of a chimeric enzyme consisting of the A-chain of cinnamomin and the B-chain of ricin or vice versa, the enzyme possessing the cinnamomin B-chain shows lower cytotoxic effects, while the catalytic activity of the A-chains is similar, overview Ricinus communis
additional information construction of a chimeric enzyme consisting of the A-chain of cinnamomin and the B-chain of ricin or vice versa, the enzyme possessing the cinnamomin B-chain shows lower cytotoxic effects, while the catalytic activity of the A-chains is similar, overview Cinnamomum camphora

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Ricinus communis the cytotoxic enzyme inhibits protein synthesis of the targeted BA/F3beta cells, the cytotoxicity is high compared to cinnamomin of Cinnamomum camphora due to the high affinity of the B-chain subunit for the cell surface ligands ?
-
?
additional information Cinnamomum camphora the cytotoxic enzyme inhibits protein synthesis of the targeted BA/F3beta cells, the cytotoxicity is low compared to ricin of Ricinus communis due to the low affinity of the B-chain subunit for the cell surface ligands ?
-
?

Organism

Organism UniProt Comment Textmining
Cinnamomum camphora
-
-
-
Ricinus communis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
seed
-
Ricinus communis
-
seed
-
Cinnamomum camphora
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the cytotoxic enzyme inhibits protein synthesis of the targeted BA/F3beta cells, the cytotoxicity is high compared to cinnamomin of Cinnamomum camphora due to the high affinity of the B-chain subunit for the cell surface ligands Ricinus communis ?
-
?
additional information the cytotoxic enzyme inhibits protein synthesis of the targeted BA/F3beta cells, the cytotoxicity is low compared to ricin of Ricinus communis due to the low affinity of the B-chain subunit for the cell surface ligands Cinnamomum camphora ?
-
?

Subunits

Subunits Comment Organism
dimer heterodimer formed by a catalytic subunit A, the A-chain, and a carbohydrate binding subunit B, the B-chain Ricinus communis
dimer heterodimer formed by a catalytic subunit A, the A-chain, and a carbohydrate binding subunit B, the B-chain Cinnamomum camphora

Synonyms

Synonyms Comment Organism
cinnamomin
-
Cinnamomum camphora
ricin
-
Ricinus communis
RNA N-glycosidase
-
Ricinus communis
RNA N-glycosidase
-
Cinnamomum camphora
type II ribosome-inactivating protein
-
Ricinus communis
type II ribosome-inactivating protein
-
Cinnamomum camphora
type II RIP
-
Ricinus communis
type II RIP
-
Cinnamomum camphora