Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Escherichia coli | the enzyme is induced in response to DNA alkylation, and it protects cells from alkylated nucleobases by catalyzing their excision | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alkylated DNA + H2O | AlkA has significant glycosylase activity towards each of the normal bases in DNA. AlkA binds nonspecifically to DNA and neither mismatches nor 7-methylguanine lesions are specifically recognized in the ground state | Escherichia coli | 3-methyladenine + 3-methylguanine + 7-methylguanine + 7-methyladenine + ? | - |
? | |
additional information | the enzyme is induced in response to DNA alkylation, and it protects cells from alkylated nucleobases by catalyzing their excision | Escherichia coli | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3-methyladenine DNA glycosylase II | - |
Escherichia coli |
AlkA | - |
Escherichia coli |