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Literature summary for 3.2.2.21 extracted from

  • Saparbaev, M.; Langouet, S.; Privezentzev, C.V.; Guengerich, F.P.; Cai, H.; Elder, R.H.; Laval, J.
    1,N(2)-ethenoguanine, a mutagenic DNA adduct, is a primary substrate of Escherichia coli mismatch-specific uracil-DNA glycosylase and human alkylpurine-DNA-N-glycosylase (2002), J. Biol. Chem., 277, 26987-26993.
    View publication on PubMed
Search for more literature for 3.2.2.21

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000024
-
 1,N6-ethenoadenine residues in alkylated DNA pH 7.5, 37°C, excision of 1, N6-ethenoadenine Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alkylated DNA + H2O Homo sapiens
-
 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,N6-ethenoadenine residues in alkylated DNA + H2O
-
 Homo sapiens ethenoadenine + DNA
-
 ?
alkylated DNA + H2O
-
 Homo sapiens 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
 ?
additional information removes N-alkylpurine damage, unrepaired DNA damage leads to carcinogenesis, cell death, and aging, also releases 1,N6-ethenoadenine Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
alkylpurine-DNA-N-glycosylase
-
 Homo sapiens
ANPG
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.000833
-
 1,N6-ethenoadenine residues in alkylated DNA pH 7.5, 37°C, excision of1, N6-ethenoadenine Homo sapiens