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Literature summary for 3.2.2.21 extracted from

  • Terato, H.; Masaoka, A.; Kobayashi, M.; Fukushima, S.; Ohyama, Y.; Yoshida, M.; Ide, H.
    Enzymatic repair of 5-formyluracil. II. Mismatch formation between 5-formyluracil and guanine during dna replication and its recognition by two proteins involved in base excision repair (AlkA) and mismatch repair (MutS) (1999), J. Biol. Chem., 274, 25144-25150.
    View publication on PubMed
Search for more literature for 3.2.2.21

Cloned(Commentary)

Cloned (Comment) Organism
-
 Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
additional information prior complex formation between mismatch repair protein MutS and a heteroduplex containing an 5-formyluracil-guanine mispair inhibits the activity of AlkA to 5-formyluracil Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alkylated DNA + H2O Escherichia coli DNA repair enzyme, inducible base excision repair pathway of DNA alkylation damage 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
 ?
alkylated DNA + H2O Escherichia coli AB1157 DNA repair enzyme, inducible base excision repair pathway of DNA alkylation damage 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 AB1157
-
Escherichia coli AB1157
-
 AB1157
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alkylated DNA + H2O
-
 Escherichia coli 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
 ?
alkylated DNA + H2O DNA repair enzyme, inducible base excision repair pathway of DNA alkylation damage Escherichia coli 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
 ?
alkylated DNA + H2O
-
 Escherichia coli AB1157 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
 ?
alkylated DNA + H2O DNA repair enzyme, inducible base excision repair pathway of DNA alkylation damage Escherichia coli AB1157 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
-
 ?
additional information repairs 5-formyluracil, a major thymine lesion produced by reactive oxygen radicals and photosensitized oxidation, 5-hydroxymethyluracil, another major thymine methyl oxidation product, is not a substrate Escherichia coli ?
-
 ?
additional information repairs 5-formyluracil, a major thymine lesion produced by reactive oxygen radicals and photosensitized oxidation, 5-hydroxymethyluracil, another major thymine methyl oxidation product, is not a substrate Escherichia coli AB1157 ?
-
 ?

Synonyms

Synonyms Comment Organism
AlkA protein
-
 Escherichia coli