Application | Comment | Organism |
---|---|---|
medicine | MPG overexpression is paradoxically associated with increased suspectibility to DNA damage, up-regulation of this gene may suggest a functional role in breast carcinogenesis, animal models using transgenic mice overexpressing the enzyme are being developed to determine the in vivo role of MPG in breast carcinogenesis | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
construction of recombinant GST-MPG fusion proteins | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32000 | - |
SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alkylated DNA + H2O | Homo sapiens | - |
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | normal, malignant and immortalized breast cells | Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MCF10A cell | immortalized, non-transformed breast epithelial cell line | Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
T47D cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alkylated DNA + H2O | - |
Homo sapiens | 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA | - |
? | |
additional information | removes N-alkylpurine damage, unrepaired DNA damage leads to carcinogenesis, cell death, and aging, also releases 1,N6-ethenoadenine | Homo sapiens | ? | - |
? |