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Literature summary for 3.2.2.20 extracted from

  • Lee, C.; Delaney, J.; Kartalou, M.; Lingaraju, G.; Maor-Shoshani, A.; Essigmann, J.; Samson, L.
    Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG) (2009), Biochemistry, 48, 1850-1861.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.20

Protein Variants

Protein Variants Comment Organism
additional information construction of a truncated DELTA80AAG enzyme mutant, substrate specificity in comparison to the wild-type enzyme shows that both the full-length and truncated AAG excise 1,N2-ethenoguanine, albeit weakly, from duplex DNA, while uracil is excised from both single- and double-stranded DNA, but only by full-length AAG, single-turnover excision kinetics, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens 3-methyladenine DNA glycosylase recognizes and excises a broad range of purines damaged by alkylation and oxidative damage, including 3-methyladenine, 7-methylguanine, hypoxanthine, and 1,N6-ethenoadenine ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information 3-methyladenine DNA glycosylase recognizes and excises a broad range of purines damaged by alkylation and oxidative damage, including 3-methyladenine, 7-methylguanine, hypoxanthine, and 1,N6-ethenoadenine Homo sapiens ?
-
 ?
additional information both the full-length and truncated AAG excised 1,N2-ethenoguanine, albeit weakly, from duplex DNA, while uracil is excised from both single- and double-stranded DNA, but only by full-length AAG. Structural basis for substrate recognition, base excision, and exclusion of normal purines and pyrimidines from its substrate recognition pocket, mechanism, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
3-methyladenine DNA glycosylase
-
 Homo sapiens
AAG
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
 additional information single-turnover excision kinetics of wild-type and mutant enzymes, overview Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
 assay at Homo sapiens