Crystallization (Comment) | Organism |
---|---|
in complex with product ADP-ribose. The interactions of the adenosine and proximal ribose occur primarily through quasidomain D due to a relative movement of the adenosine moiety by 8.4 A and a rotation of about 105°. Comparison with ADP-ribose glycohydrolase ARH3 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | The activity is abolished upon mutation of even a single Mg2+ coordinating residue | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP-ribose | - |
Homo sapiens | |
CaCl2 | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required. The presence of both Mg2+ ions is required for the correct positioning of the distal ribose. The activity is abolished upon mutation of even a single Mg2+ coordinating residue | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P54922 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
ADPRH | - |
Homo sapiens |
ARH1 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.164 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | CaCl2 | |
0.228 | - |
pH 7.4, temperature not specified in the publication | Homo sapiens | ADP-ribose |