Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.2.1 extracted from

  • Berg, M.; Bal, G.; Goeminne, A.; Van der Veken, P.; Versees, W.; Steyaert, J.; Haemers, A.; Augustyns, K.
    Synthesis of bicyclic N-arylmethyl-substituted iminoribitol derivatives as selective nucleoside hydrolase inhibitors (2009), ChemMedChem, 4, 249-260.
    View publication on PubMed
Search for more literature for 3.2.2.1

Inhibitors

Inhibitors Comment Organism Structure
(2R,3R,4S)-1-[(4-amino-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-2-(hydroxymethyl)pyrrolidine-3,4-diol
-
 Trypanosoma vivax
(2R,3R,4S)-2-(hydroxymethyl)-1-(quinolin-8-ylmethyl)pyrrolidine-3,4-diol
-
 Trypanosoma vivax
1,4-dideoxy-1,4-imino-N-(2(1H)-quinolon-8-yl)methyl-D-ribitol
-
 Trypanosoma vivax
1,4-dideoxy-1,4-imino-N-(2-amino-4-benzothiazoyl)-methyl-D-ribitol
-
 Trypanosoma vivax
1,4-dideoxy-1,4-imino-N-(2-aminoquinolin-8-yl)methyl-D-ribitol
-
 Trypanosoma vivax
1,4-dideoxy-1,4-imino-N-(2-chloroquinolin-8-yl)methyl-D-ribitol
-
 Trypanosoma vivax
1,4-dideoxy-1,4-imino-N-(2-methoxyquinolin-8-yl)methyl-D-ribitol
-
 Trypanosoma vivax
1,4-dideoxy-1,4-imino-N-(4(1H)-quinolon-8-yl)methyl-D-ribitol
-
 Trypanosoma vivax
1,4-dideoxy-1,4-imino-N-(4-amino-2-methylquinolin-8-yl)methyl-D-ribitol
-
 Trypanosoma vivax
1,4-dideoxy-1,4-imino-N-(4-aminoquinazolin-8-yl)methyl-D-ribitol
-
 Trypanosoma vivax
1,4-dideoxy-1,4-imino-N-(4-aminoquinolin-8-yl)methyl-D-ribitol
-
 Trypanosoma vivax
1,4-dideoxy-1,4-imino-N-(4-aminothieno[3,2-d]pyrimidin-7-yl)-methyl-D-ribitol
-
 Trypanosoma vivax
1,4-dideoxy-1,4-imino-N-(4-chloro-2-methylquinolin-8-yl)methyl-D-ribitol
-
 Trypanosoma vivax
1,4-dideoxy-1,4-imino-N-(4-chloroquinolin-8-yl)methyl-D-ribitol
-
 Trypanosoma vivax
1,4-dideoxy-1,4-imino-N-(4-methoxyquinolin-8-yl)methyl-D-ribitol
-
 Trypanosoma vivax
1,4-dideoxy-1,4-imino-N-(7-thieno[3,2-d]pyrimidonyl)-methyl-D-ribitol
-
 Trypanosoma vivax
1,4-dideoxy-1,4-imino-N-(quinazolin-8-yl)methyl-D-ribitol
-
 Trypanosoma vivax
1,4-dideoxy-1,4-imino-N-(quinazolon-8-yl)methyl-D-ribitol
-
 Trypanosoma vivax
1,4-dideoxy-1,4-imino-N-(quinoxalin-5-yl)-methyl-D-ribitol
-
 Trypanosoma vivax
1,4-dideoxy-1,4-imino-N-(thieno[3,2-d]pyrimidin-7-yl)methyl-D-ribitol
-
 Trypanosoma vivax
7-[[(2R,3R,4S)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-yl]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
-
 Trypanosoma vivax
immucillin A
-
 Trypanosoma vivax
immucillin H
-
 Trypanosoma vivax

Organism

Organism UniProt Comment Textmining
Trypanosoma vivax Q9GPQ4
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inosine + H2O
-
 Trypanosoma vivax hypoxanthine + D-ribose
-
 ?

Synonyms

Synonyms Comment Organism
IAG-NH
-
 Trypanosoma vivax
inosine-adenosine-guanosine-preferring nucleoside hydrolase
-
 Trypanosoma vivax
purine-specific NH
-
 Trypanosoma vivax

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000041
-
 (2R,3R,4S)-1-[(4-amino-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-2-(hydroxymethyl)pyrrolidine-3,4-diol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
0.0000044
-
 7-[[(2R,3R,4S)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-yl]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
0.0000108
-
 (2R,3R,4S)-2-(hydroxymethyl)-1-(quinolin-8-ylmethyl)pyrrolidine-3,4-diol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
0.000014
-
 1,4-dideoxy-1,4-imino-N-(4-chloroquinolin-8-yl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
0.000015
-
 1,4-dideoxy-1,4-imino-N-(4-aminoquinazolin-8-yl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
0.000019
-
 1,4-dideoxy-1,4-imino-N-(4-aminothieno[3,2-d]pyrimidin-7-yl)-methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
0.00002
-
 1,4-dideoxy-1,4-imino-N-(7-thieno[3,2-d]pyrimidonyl)-methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
0.000029
-
 1,4-dideoxy-1,4-imino-N-(4-methoxyquinolin-8-yl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
0.00004
-
 1,4-dideoxy-1,4-imino-N-(2-amino-4-benzothiazoyl)-methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
0.000042
-
 1,4-dideoxy-1,4-imino-N-(thieno[3,2-d]pyrimidin-7-yl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
0.00005
-
 1,4-dideoxy-1,4-imino-N-(4-aminoquinolin-8-yl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
0.000058
-
 1,4-dideoxy-1,4-imino-N-(quinazolin-8-yl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
0.000109
-
 1,4-dideoxy-1,4-imino-N-(quinazolon-8-yl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
0.000139
-
 1,4-dideoxy-1,4-imino-N-(quinoxalin-5-yl)-methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
0.000314
-
 1,4-dideoxy-1,4-imino-N-(2-chloroquinolin-8-yl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
0.000369
-
 1,4-dideoxy-1,4-imino-N-(4-chloro-2-methylquinolin-8-yl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
0.001258
-
 1,4-dideoxy-1,4-imino-N-(2-methoxyquinolin-8-yl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
0.00836
-
 1,4-dideoxy-1,4-imino-N-(2-aminoquinolin-8-yl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
0.0131
-
 1,4-dideoxy-1,4-imino-N-(4(1H)-quinolon-8-yl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
0.0713
-
 1,4-dideoxy-1,4-imino-N-(4-amino-2-methylquinolin-8-yl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax
0.187
-
 1,4-dideoxy-1,4-imino-N-(2(1H)-quinolon-8-yl)methyl-D-ribitol in 50 mM phosphate buffer, pH 7.0, at 35°C Trypanosoma vivax