Literature summary for 3.2.1.59 extracted from

Bajaj, I.; Veiga, T.; van Dissel, D.; Pronk, J.T.; Daran, J.M.
Functional characterization of a Penicillium chrysogenum mutanase gene induced upon co-cultivation with Bacillus subtilis (2014), BMC Microbiol., 14, 114.

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Application

Application	Comment	Organism
pharmacology	the enzyme may enhance the efficacy of fungal antibiotics by degrading bacterial exopolysaccharides	Penicillium chrysogenum

Cloned(Commentary)

Cloned (Comment)	Organism
gene Pc12g07500, heterologous expression in Saccharomyces cerevisiae strain IME208 confirms that Pc12g07500 encodes an active alpha-1,3 endoglucanase, secretion of the recombinant enzyme to culture medium	Penicillium chrysogenum
gene Pc12g13330, heterologous expression in Saccharomyces cerevisiae strain IME208 confirmes that Pc12g13330 encodes an inactive alpha-1,3 endoglucanase, secretion of the recombinant enzyme to culture medium	Penicillium chrysogenum

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	the enzyme contains a signal peptide	Penicillium chrysogenum	-	-

Organism

Organism	UniProt	Comment	Textmining
no activity in Bacillus subtilis	-	-	-
Penicillium chrysogenum	B6GX22	gene Pc12g07500	-
Penicillium chrysogenum	B6GZT2	gene Pc12g13330	-
Penicillium chrysogenum Wisconsin 54-1255	B6GX22	gene Pc12g07500	-
Penicillium chrysogenum Wisconsin 54-1255	B6GZT2	gene Pc12g13330	-

Synonyms

Synonyms	Comment	Organism
alpha-1,3 endoglucanase	-	Penicillium chrysogenum
mutanase	-	Penicillium chrysogenum

Expression

Organism	Comment	Expression
Penicillium chrysogenum	co-cultivation with Bacillus subtilis induces mutanase production from gene Pc12g07500 by 15fold	up
Penicillium chrysogenum	co-cultivation with Bacillus subtilis induces mutanase production from gene Pc12g13330 by 8fold	up

General Information

General Information	Comment	Organism
additional information	interaction and transcriptional responses analysis between Penicillium chrysogenum and Bacillus subtilis, overview	Penicillium chrysogenum

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Release 2023.1 (January 2023)