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Literature summary for 3.2.1.52 extracted from

  • Chen, W.; Shen, S.; Dong, L.; Zhang, J.; Yang, Q.
    Selective inhibition of beta-N-acetylhexosaminidases by thioglycosyl-naphthalimide hybrid molecules (2018), Bioorg. Med. Chem., 26, 394-400 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Pichia pastoris Ostrinia furnacalis

Inhibitors

Inhibitors Comment Organism Structure
2-amino-1H-benzo[de]isoquinoline-1,3(2H)-dione 28.1% inhibition at 0.1 mM Ostrinia furnacalis
2-[[1-[(2-acetamido-beta-D-glucopyranosylthiomethyl)-1H-1,2,3-triazol-4-yl]methyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione 17.9% inhibition at 0.1 mM Ostrinia furnacalis
2-[[1-[2-[(2-acetamido-beta-D-glucopyranosyl)thio]ethyl]-1H-1,2,3-triazol-4-yl]methyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione 84% inhibition at 0.1 mM Ostrinia furnacalis
2-[[1-[3-[(2-acetamido-beta-D-glucopyranosyl)thio]propyl]-1H-1,2,3-triazol-4-yl]methyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione 81.6% inhibition at 0.1 mM Ostrinia furnacalis
2-[[1-[4-[(2-acetamido-beta-D-glucopyranosyl)thio]butyl]-1H-1,2,3-triazol-4-yl]methyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione 89.9% inhibition at 0.1 mM Ostrinia furnacalis
2-[[1-[5-[(2-acetamido-beta-D-glucopyranosyl)thio]pentyl]-1H-1,2,3-triazol-4-yl]methyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione 91.9% inhibition at 0.1 mM Ostrinia furnacalis
2-[[1-[6-[(2-acetamido-beta-D-glucopyranosyl)thio]hexyl]-1H-1,2,3-triazol-4-yl]methyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione 93.2% inhibition at 0.1 mM Ostrinia furnacalis
LOGNAc i.e. 2-acetamido-2-deoxy-D-gluconhydroximo-1,5-lactone Ostrinia furnacalis
N-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-2-[(2-acetamido-beta-D-glucopyranosyl)thio]acetamide 24.9% inhibition at 0.1 mM Ostrinia furnacalis
N-[2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl]-2-[(2-acetamido-beta-D-glucopyranosyl) thio]acetamide 18.4% inhibition at 0.1 mM Ostrinia furnacalis
N-[2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl]-2-[(2-acetamido-beta-D-glucopyranosyl)thio]acetamide 18.4% inhibition at 0.1 mM Ostrinia furnacalis
N-[2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl]-3-[(2-acetamido-beta-D-glucopyranosyl)thio]propanamide 25.8% inhibition at 0.1 mM Ostrinia furnacalis
N-[3-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propyl]-2-[(2-acetamido-beta-D-glucopyranosyl)thio]acetamide 29.2% inhibition at 0.1 mM Ostrinia furnacalis
N-[3-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propyl]-3-[(2-acetamido-beta-D-glucopyranosyl)thio]propanamide 25.3% inhibition at 0.1 mM Ostrinia furnacalis
N-[4-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)butyl]-2-[(2-acetamido-beta-D-glucopyranosyl)thio]acetamide 29.1% inhibition at 0.1 mM Ostrinia furnacalis
N-[4-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)butyl]-3-[(2-acetamido-beta-D-glucopyranosyl)thio]propanamide 26.9% inhibition at 0.1 mM Ostrinia furnacalis
NAG-thiazoline
-
Ostrinia furnacalis
naphthalimide
-
Ostrinia furnacalis
PUGNAc i.e. O-(2-acetamido-2-deoxy-D-glucopyranosylidenamino) N-phenylcarbamate, 97.5% inhibition at 0.1 mM Ostrinia furnacalis

Organism

Organism UniProt Comment Textmining
Ostrinia furnacalis Q06GJ0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl N-acetyl-beta-D-glucosaminide + H2O
-
Ostrinia furnacalis 4-methylumbelliferone + N-acetyl-beta-D-glucosamine
-
?

Synonyms

Synonyms Comment Organism
Hex1
-
Ostrinia furnacalis