Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target for GlcNAc-inspired iminocyclitiols drug development | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-acetamido-1,2,5-trideoxy-1,5-imino-D-glucitol | - |
Homo sapiens | |
additional information | synthesis and development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors, inhibitor enzyme interactions and binding structures, overview | Homo sapiens | |
N-((3S,4R,5S)-1-(7-(bis(4-methoxybenzyl)amino)heptyl)-4,5-dihydroxy-5-(hydroxymethyl)piperidin-3-yl)acetamide | - |
Homo sapiens | |
N-((3S,4R,5S)-4,5-dihydroxy-5-(hydroxymethyl)-1-(7-(4-methoxybenzylamino)heptyl)piperidin-3-yl)acetamide | - |
Homo sapiens | |
N-(7-((3S,4R,5S)-5-acetamido-3,4-dihydroxy-3-(hydroxymethyl)piperidin-1-yl)heptyl)-5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide | - |
Homo sapiens | |
N-[1(7-amino-heptyl)]-2-acetamido-1,2,5-trideoxy-1,5-imino-D-glucitol | competitive inhibitor | Homo sapiens | |
N-[1(7-azido-heptyl)]-2-acetamido-1,2,5-trideoxy-1,5-imino-D-glucitol | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme Hex B | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
chondrocyte | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Hex | - |
Homo sapiens |
N-acetyl-beta-hexosaminidase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.25 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000069 | - |
N-((3S,4R,5S)-1-(7-(bis(4-methoxybenzyl)amino)heptyl)-4,5-dihydroxy-5-(hydroxymethyl)piperidin-3-yl)acetamide | pH 4.25, 30°C, isozyme Hex B | Homo sapiens | |
0.0000012 | - |
N-((3S,4R,5S)-4,5-dihydroxy-5-(hydroxymethyl)-1-(7-(4-methoxybenzylamino)heptyl)piperidin-3-yl)acetamide | pH 4.25, 30°C, isozyme Hex B | Homo sapiens | |
0.0000021 | - |
N-[1(7-amino-heptyl)]-2-acetamido-1,2,5-trideoxy-1,5-imino-D-glucitol | pH 4.25, 30°C, isozyme Hex B | Homo sapiens | |
0.0000267 | - |
N-(7-((3S,4R,5S)-5-acetamido-3,4-dihydroxy-3-(hydroxymethyl)piperidin-1-yl)heptyl)-5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide | pH 4.25, 30°C, isozyme Hex B | Homo sapiens | |
0.00054 | - |
2-acetamido-1,2,5-trideoxy-1,5-imino-D-glucitol | pH 4.25, 30°C, isozyme Hex B | Homo sapiens | |
0.0017 | - |
N-[1(7-azido-heptyl)]-2-acetamido-1,2,5-trideoxy-1,5-imino-D-glucitol | pH 4.25, 30°C, isozyme Hex B | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | Hex is linked to osteoarthritis and lysosomal storage disorders | Homo sapiens |
physiological function | Hex is the predominant glycosidase released by chondrocytes to degrade glycosaminoglycan | Homo sapiens |