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Literature summary for 3.2.1.52 extracted from

  • Prence, E.M.; Zalewski, I.; Natowicz, M.R.
    Unusual thermolability properties of beta-hexosaminidase: Studies of enzyme from cultured cells and clinical implications (1996), Am. J. Med. Genet., 65, 320-324.
    View publication on PubMed
Search for more literature for 3.2.1.52

Application

Application Comment Organism
medicine diagosis of Tay-Sachs disease Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-beta-D-hexosaminides + H2O Homo sapiens
-
 N-acetyl-D-hexosamines
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 patients with Tay-Sachs-disease
-

Source Tissue

Source Tissue Comment Organism Textmining
amniotic fluid
-
 Homo sapiens
-
chorionic villus
-
 Homo sapiens
-
fibroblast
-
 Homo sapiens
-
leukocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-glucopyranoside + H2O
-
 Homo sapiens 4-methylumbelliferone + 2-acetamido-2-deoxy-beta-D-glucopyranoside
-
 ?
4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-glucopyranoside-6-sulfate + H2O
-
 Homo sapiens 4-methylumbelliferone + 2-acetamido-2-deoxy-beta-D-glucopyranoside-6-sulfate
-
 ?
N-acetyl-beta-D-hexosaminides + H2O
-
 Homo sapiens N-acetyl-D-hexosamines
-
 ?

Subunits

Subunits Comment Organism
dimer Hex A: alpha beta, Hex B: beta beta Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50 52 Hex A is labile, Hex B is stable, at lower sample concentrations Hex B is less stable at 52°C Homo sapiens