Literature summary for 3.2.1.51 extracted from

Cheng, T.; Tu, S.; Chen, L.; Chen, M.; Chen, W.; Lin, Y.; Ho, C.; Lin, S.; Wu, C.; Ho, Y.
Down-regulation of ?-L-fucosidase 1 expression confers inferior survival for triple-negative breast cancer patients by modulating the glycosylation status of the tumor cell surface. (2015), Oncotarget, 6, 21283-21300.

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Application

Application	Comment	Organism
medicine	the enzyme is an indicator of poor prognosis for patients with advanced-stage triple-negative breast cancer	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
deoxyfuconojirimycin	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
lysosome	-	Homo sapiens	5764	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P04066	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
AU-565 cell	-	Homo sapiens	-
breast	-	Homo sapiens	-
breast tumor cell	-	Homo sapiens	-
BT-474 cell	-	Homo sapiens	-
BT-483 cell	-	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-
MDA-MB-453 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
alpha-L-fucosidase 1	-	Homo sapiens
Fuca1	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	there is a greater than 139fold increase in enzyme mRNA expression in breast tumor samples compared with normal breast tissue	up

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Release 2023.1 (January 2023)