BRENDA - Enzyme Database
show all sequences of 3.2.1.48

Dietary phenolic compounds selectively inhibit the individual subunits of maltase-glucoamylase and sucrase-isomaltase with the potential of modulating glucose release

Simsek, M.; Quezada-Calvillo, R.; Ferruzzi, M.G.; Nichols, B.L.; Hamaker, B.R.; J. Agric. Food Chem. 63, 3873-3879 (2015)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression in Drosophila S2 cells; recombinant expression in a baculovirus-Sf9 insect cell system
Homo sapiens
expression in Drosophila S2 cells; recombinant expression in a baculovirus-Sf9 insect cell system
Mus musculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
(+)-catechin
noncompetitive
Homo sapiens
(+)-catechin
noncompetitive
Mus musculus
(-)-epigallocatechin gallate
noncompetitive
Homo sapiens
(-)-epigallocatechin gallate
noncompetitive
Mus musculus
caffeic acid
noncompetitive
Homo sapiens
caffeic acid
noncompetitive
Mus musculus
chlorogenic acid
noncompetitive
Homo sapiens
chlorogenic acid
noncompetitive
Mus musculus
gallic acid
noncompetitive
Homo sapiens
gallic acid
noncompetitive
Mus musculus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
P14410
-
-
Mus musculus
B5THE3
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
maltose + H2O
-
750886
Homo sapiens
alpha-D-glucose
-
-
-
?
maltose + H2O
-
750886
Mus musculus
alpha-D-glucose
-
-
-
?
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in Drosophila S2 cells; recombinant expression in a baculovirus-Sf9 insect cell system
Homo sapiens
expression in Drosophila S2 cells; recombinant expression in a baculovirus-Sf9 insect cell system
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
(+)-catechin
noncompetitive
Homo sapiens
(+)-catechin
noncompetitive
Mus musculus
(-)-epigallocatechin gallate
noncompetitive
Homo sapiens
(-)-epigallocatechin gallate
noncompetitive
Mus musculus
caffeic acid
noncompetitive
Homo sapiens
caffeic acid
noncompetitive
Mus musculus
chlorogenic acid
noncompetitive
Homo sapiens
chlorogenic acid
noncompetitive
Mus musculus
gallic acid
noncompetitive
Homo sapiens
gallic acid
noncompetitive
Mus musculus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
maltose + H2O
-
750886
Homo sapiens
alpha-D-glucose
-
-
-
?
maltose + H2O
-
750886
Mus musculus
alpha-D-glucose
-
-
-
?
Other publictions for EC 3.2.1.48
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
750717
Henstroem
Functional variants in the su ...
Homo sapiens
Gut
67
263-270
2018
-
-
-
-
1
-
-
-
-
-
-
-
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4
-
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1
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-
-
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1
1
-
-
-
751091
Gericke
Structure-function analysis o ...
Homo sapiens
J. Biol. Chem.
292
11070-11078
2017
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-
1
-
12
-
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6
2
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1
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2
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2
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5
-
1
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1
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1
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12
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1
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6
2
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1
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-
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2
-
-
5
-
1
-
-
-
1
-
-
-
-
5
5
-
-
-
750886
Simsek
Dietary phenolic compounds se ...
Homo sapiens, Mus musculus
J. Agric. Food Chem.
63
3873-3879
2015
-
-
2
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-
10
-
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4
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2
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2
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10
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2
-
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-
-
715207
Singh
A novel sucrose/H+ symport sys ...
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41
817-826
2011
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1
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1
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1
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-
-
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Sim
Structural basis for substrate ...
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-
1
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-
6
1
1
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-
3
1
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-
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2
-
-
-
-
-
-
1
-
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-
2
2
3
1
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-
2
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-
1
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6
1
1
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3
1
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Gupta
Inhibition of brush border suc ...
Mus musculus
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3
4
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1
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1
1
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-
1
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3
-
4
1
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1
1
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1
-
1
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1
1
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1
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708404
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Structural changes and inhibit ...
Homo sapiens, Saccharomyces cerevisiae
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-
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1
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1
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3
-
1
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-
1
1
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-
2
-
1
-
-
-
-
-
-
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1
3
2
2
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-
1
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1
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3
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1
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1
1
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2
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2
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698080
Alfalah
Compound heterozygous mutation ...
Homo sapiens
Gastroenterology
136
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-
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1
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4
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2
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1
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4
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702506
Wetzel
Impact of glycosylation and de ...
Homo sapiens
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-
-
-
-
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-
1
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1
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1
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2
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1
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1
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-
-
-
706954
Champion
The apo structure of sucrose h ...
Xanthomonas campestris pv. campestris
Acta Crystallogr. Sect. D
65
1309-1314
2009
-
-
-
1
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1
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1
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3
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2
1
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1
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1
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1
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1
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1
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-
-
2
1
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-
1
-
1
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-
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4
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688420
Kim
Crystal structures and mutagen ...
Xanthomonas axonopodis
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636-647
2008
-
-
1
1
8
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7
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2
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7
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1
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1
8
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7
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1
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2
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7
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-
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-
694604
Kim
Potent alpha-glucosidase inhib ...
Rattus norvegicus
Phytochemistry
69
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2008
-
1
-
-
-
-
5
-
-
-
-
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1
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1
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4
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1
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4
5
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1
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721339
Comfort
Functional-genomics-based iden ...
Pyrococcus furiosus
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74
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2008
-
-
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-
4
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1
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4
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4
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1
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1
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5
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4
-
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-
-
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1
1
-
4
4
677949
Gu
HNF-1alpha participates in glu ...
Homo sapiens
Biochem. Biophys. Res. Commun.
353
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2007
1
-
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1
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Honma
Carbohydrate/fat ratio in the ...
Mus musculus
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2007
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Homo sapiens
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Adeola
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Sus scrofa
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666140
Gu
Sucrase-isomaltase gene expres ...
Homo sapiens
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2006
1
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Zheng
-
Inhibition of porcine small in ...
Sus scrofa
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2
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1
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1
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1
1
1
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1
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1
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2
1
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1
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1
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1
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665799
Proepsting
A phenylalanine-based folding ...
Homo sapiens
J. Cell Sci.
118
2775-2784
2005
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1
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2
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1
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2
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1
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1
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1
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1
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665941
Karley
Significance of gut sucrase ac ...
Acyrthosiphon pisum
J. Insect Physiol.
51
1313-1319
2005
-
-
-
-
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3
-
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2
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1
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3
-
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3
-
1
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3
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3
3
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2
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3
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3
-
1
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-
655879
Kim
Molecular and functional chara ...
Xanthomonas axonopodis
J. Bacteriol.
186
411-418
2004
-
-
1
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1
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1
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1
-
-
-
-
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3
1
1
1
2
-
1
1
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-
-
1
-
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1
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1
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1
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1
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3
1
1
1
2
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663852
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Effect of mutations in HNF-1al ...
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2004
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664558
Martin-Latil
A cyclic AMP protein kinase A- ...
Homo sapiens
Cell. Microbiol.
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2004
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2
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1
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656123
Proepsting
A glutamine to proline exchang ...
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J. Biol. Chem.
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2003
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655295
Mukherjee
Regulation of cellobiase secre ...
Termitomyces clypeatus
Curr. Microbiol.
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2002
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3
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655706
Kaur
Effect of harmaline on rat int ...
Rattus norvegicus
INDIAN J. Biochem. Biophys.
39
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2002
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656071
Jacob
Sucrase is an intramolecular c ...
Homo sapiens
J. Biol. Chem.
277
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2002
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656897
Petersen
Glucagon-like peptide 2 enhanc ...
Sus scrofa
Pediatr. Res.
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2002
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1
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655668
Finn
Sucrase-isomaltase is an adeno ...
Necturus maculosus
Gastroenterology
120
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2001
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655167
Hertel
Hydrolysis of low-molecular-we ...
Sus scrofa
Carbohydr. Res.
326
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2000
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10
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136522
Schönert
Identification and enzymatic c ...
Bacillus subtilis
J. Bacteriol.
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1998
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5
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1
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136521
Holt
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Cloning and characterization o ...
Leuconostoc mesenteroides
Biotechnol. Lett.
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1997
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136520
Kano
Inhibition of purified human s ...
Homo sapiens
Biol. Pharm. Bull.
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1996
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1
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8
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2
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8
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1
1
2
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-
-
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-
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136519
Norman
Characterization of levJ, a su ...
Actinomyces naeslundii, Actinomyces naeslundii T14V
Gene
152
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1995
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1
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4
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10
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136518
Quezada-Calvillo
-
Murine intestinal disaccharida ...
Mus musculus
Am. J. Physiol.
265
1142-1149
1993
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1
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1
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2
1
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1
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136517
Fransen
Naturally occuring mutations i ...
Homo sapiens
J. Cell Biol.
115
45-47
1991
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2
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2
1
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136510
Muto
Enzymatic formation of a nonre ...
Rattus rattus
J. Biochem.
107
222-227
1990
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1
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4
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1
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1
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136511
Vasseur
pH-Dependent inhibitory effect ...
Oryctolagus cuniculus
J. Enzyme Inhib.
4
15-26
1990
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1
2
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136512
Galand
First purification and charact ...
Anser anser
Biochim. Biophys. Acta
1033
35-40
1990
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2
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1
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1
1
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2
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1
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-
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-
-
-
-
-
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-
-
136513
Beaulieu
Detection and characterization ...
Homo sapiens
Gastroenterology
98
1467-1477
1990
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1
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1
2
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2
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2
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2
1
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1
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2
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1
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2
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2
1
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-
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-
-
-
-
-
-
-
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136514
Teo
-
Some properties of the sucrase ...
Achatina fulica, Arion ater, Perna viridis
Comp. Biochem. Physiol. B
96
47-51
1990
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1
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6
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3
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6
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2
1
1
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3
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5
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1
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6
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6
-
2
1
1
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3
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136515
Sandhu
Kinetic characteristics of sol ...
Rattus rattus
Indian J. Biochem. Biophys.
27
88-92
1990
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2
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2
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2
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2
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2
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136516
Kapadia
Some properties of monkey inte ...
Platyrrhini
Indian J. Biochem. Biophys.
27
93-97
1990
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6
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1
1
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6
1
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1
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2
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6
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2
3
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1
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1
1
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6
1
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1
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-
-
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136500
Vasseur
Alkali-metal-ion- and H+-depen ...
Oryctolagus cuniculus
Biochem. J.
251
667-675
1988
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1
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2
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3
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2
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2
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136497
Houck
Isolation of DNA encoding sucr ...
Streptococcus salivarius
J. Bacteriol.
169
3679-3684
1987
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1
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1
1
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1
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2
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2
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-
-
-
1
-
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-
136501
Trugnan
Castanospermine: a potent inhi ...
Homo sapiens
FEBS Lett.
195
28-32
1986
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1
1
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2
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1
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-
-
2
-
-
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136498
Abe
Some properties of luminal suc ...
Rattus rattus
J. Nutr. Sci. Vitaminol.
31
243-252
1985
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2
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136499
Matsushita
Purification and partial chara ...
Gallus gallus
Comp. Biochem. Physiol. B
76
465-470
1983
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3
1
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1
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3
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3
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5
1
1
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1
1
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3
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1
-
1
1
3
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1
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-
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5
1
1
-
-
-
1
1
-
-
-
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-
136502
Vasseur
Sodium-dependent activation of ...
Oryctolagus cuniculus
Arch. Biochem. Biophys.
218
263-274
1982
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-
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2
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2
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2
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1
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2
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2
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1
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2
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2
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1
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2
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136503
Montgomery
Rat intestinal microvillus mem ...
Rattus rattus
Biochim. Biophys. Acta
661
346-349
1981
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2
1
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1
2
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1
2
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2
1
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2
1
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1
2
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1
2
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2
1
-
-
-
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136504
Hanozet
An example of enzyme hysteresi ...
Oryctolagus cuniculus
J. Biol. Chem.
256
3703-3711
1981
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3
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2
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1
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3
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2
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-
-
2
-
-
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-
-
1
-
-
-
-
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-
-
-
-
136508
Sjöström
A fully active, two-active-sit ...
Sus scrofa
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11332-11338
1980
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136506
Hauri
Biogenesis of intestinal plasm ...
Rattus rattus
Proc. Natl. Acad. Sci. USA
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5183-5186
1979
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136505
Conklin
Human intestinal sucrase-isoma ...
Homo sapiens
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5735-5741
1975
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136507
Sigrist
A hydrophobic form of the smal ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
406
433-446
1975
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136509
Kolinska
Separation and characterizatio ...
Rattus rattus
Biochim. Biophys. Acta
284
235-247
1972
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