Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | transcription factors HNF-1alpha and HNF-1beta induce constitutive enzyme expression by direct binding to sites SIF2 and SIF3 of the SI gene promoter | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of transcription factors HNF-1alpha and HNF-1beta mutants HNF-1lphaT539fsdelC and HNF-1betaR177X in Caco-2 cells reduces the sucrase-isomaltase activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme expression is transactivated by transcription factors hepatocyte nuclear factors 1alpha and 1beta, HNF-1alpha and HNF-1beta, molecular mechanism and responsible amino acids of HNFs, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Caco-2 cell | - |
Homo sapiens | - |
small intestine | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme expression is transactivated by transcription factors hepatocyte nuclear factors 1alpha and 1beta, HNF-1alpha and HNF-1beta, molecular mechanism and responsible amino acids of HNFs, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SI | - |
Homo sapiens |
sucrase-isomaltase | - |
Homo sapiens |