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Literature summary for 3.2.1.48 extracted from

  • Zheng, Y.; Shentu, X.; Shen, Y.
    Inhibition of porcine small intestinal sucrase by valienamine (2005), Chin. J. Chem. Engin., 13, 429-432.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
valienamine an aminocyclitol, isolated from the enzymolysis broth of validamycins, configuration is similar to alpha-D-glucose, IC50 in vitro is 1.17 mM, the inhibition is pH-dependent and competitive, 80% inhibition at 2.5 mM and pH 6.6 Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sucrose + H2O Sus scrofa
-
alpha-D-glucose + D-fructose
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partially from intestinal mucosa by ammonium sulfate precipitation Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
intestinal mucosa
-
Sus scrofa
-
small intestine
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sucrose + H2O
-
Sus scrofa alpha-D-glucose + D-fructose
-
?

Synonyms

Synonyms Comment Organism
sucrase
-
Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.6
-
-
Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.77
-
valienamine pH 6.6, 37°C Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.17
-
an aminocyclitol, isolated from the enzymolysis broth of validamycins, configuration is similar to alpha-D-glucose, IC50 in vitro is 1.17 mM, the inhibition is pH-dependent and competitive, 80% inhibition at 2.5 mM and pH 6.6 Sus scrofa valienamine