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Literature summary for 3.2.1.48 extracted from
- A glutamine to proline exchange at amino acid residue 1098 in sucrase causes a temperature-sensitive arrest of sucrase-isomaltase in the endoplasmic reticulum and cis-Golgi (2003), J. Biol. Chem., 278, 16310-16314.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| transfection in COS-1 cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| Q1098P | the mutation causes a temperature-sensitive arrest of enzyme in the endoplasmic reticulum and cis-Golgi, at 20°C the mutant shows 93% activity in comparison to 100% activity of wild-type enzyme. At 37°C the mutant shows 10% activity in comparison to 100% activity of wild-type enzyme | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
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Release 2023.1 (January 2023)
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