Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | a lysosomal integral membrane protein type-2 helix 5-derived peptide fused to a cellpenetrating peptide can be used to activate endogenous as well as recombinant wild-type or mutant enzyme efficiently | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
F213I | the mutation is associated with Gaucher's disease | Homo sapiens |
I161S | the mutation is associated with Gaucher's disease | Homo sapiens |
L156E | the mutant shows strongly reduced activity compared to the wild type enzyme | Homo sapiens |
L91E | the mutant shows strongly reduced activity compared to the wild type enzyme | Homo sapiens |
L94E | the mutant shows strongly reduced activity compared to the wild type enzyme | Homo sapiens |
N188S | the mutation is associated with Gaucher's disease | Homo sapiens |
N370S | the mutation is associated with Gaucher's disease | Homo sapiens |
P159L | the mutation is associated with Gaucher's disease | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P04062 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl beta-D-glucopyranoside + H2O | - |
Homo sapiens | 4-methylumbelliferone + beta-D-glucopyranose | - |
? | |
4-nitrophenyl beta-D-glucopyranoside + H2O | - |
Homo sapiens | 4-nitrophenol + beta-D-glucopyranose | - |
? | |
4-nitrophenyl N-acetyl-beta-D-glucosaminide + H2O | - |
Homo sapiens | 4-nitrophenol + N-acetyl-beta-D-glucosamine | - |
? | |
5-(pentafluorobenzoylamino)fluorescein di-beta-D-glucopyranoside + H2O | - |
Homo sapiens | 5-(pentafluorobenzoylamino)fluorescein + 2 beta-D-glucopyranose | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 60000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
beta-glucocerebrosidase | - |
Homo sapiens |