Literature summary for 3.2.1.45 extracted from

Yadav, A.K.; Shen, D.L.; Shan, X.; He, X.; Kermode, A.R.; Vocadlo, D.J.
Fluorescence-quenched substrates for live cell imaging of human glucocerebrosidase activity (2015), J. Am. Chem. Soc., 137, 1181-1189 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
AT3375	-	Homo sapiens
conduritol B epoxide	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
lysosome	-	Homo sapiens	5764	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P04062	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3-amido-(Black Hole Quencher 2)-6-methoxytriazolyl-1'-ethyl-3'-amido-(boron-dipyrromethene 576/589) beta-D-glucopyranoside + H2O	-	Homo sapiens	6-methoxytriazolyl-1'-ethyl-3'-amido-(boron-dipyrromethene 576/589) beta-D-glucopyranoside + Black Hole Quencher 2-N-(3-hydroxypropyl)butanamide	-	?
3-amido-[4-[[4-(dimethylamino)phenyl]azo]-benzoic acid]-L-6-methoxytriazol-5-[(2-azidoethyl)amino]naphthalene-1-sulfonic acid beta-D-glucopyranoside + H2O	-	Homo sapiens	6-O-[(1-[2-[(5-sulfonaphthalen-1-yl)amino]ethyl]-1H-1,2,3-triazol-4-yl)methyl]-beta-D-glucopyranose + 4-[(Z)-[4-(dimethylamino)phenyl]diazenyl]-N-(3-hydroxypropyl)benzamide	-	?
4-methylumbelliferyl beta-D-glucoside + H2O	-	Homo sapiens	4-methylumbelliferone + beta-D-glucose	-	?

Synonyms

Synonyms	Comment	Organism
acid beta-glucosidase	-	Homo sapiens
GBA1	-	Homo sapiens
Gcase	-	Homo sapiens
glucocerebrosidase	-	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
5.5	-	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	enzyme deficiency leads to abnormal accumulation of glucosyl ceramide in lysosomes and the development of the lysosomal storage disease known as Gauchers disease	Homo sapiens

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Release 2023.1 (January 2023)