Literature summary for 3.2.1.45 extracted from

Mishra, A.; Chandravanshi, L.P.; Trigun, S.K.; Krishnamurthy, S.
Ambroxol modulates 6-hydroxydopamine-induced temporal reduction in glucocerebrosidase (GCase) enzymatic activity and Parkinsons disease symptoms (2018), Biochem. Pharmacol., 155, 479-493 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
ambroxol	-	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
6-Hydroxydopamine	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
striatum	-	Rattus norvegicus	-
substantia nigra	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-methylumbelliferyl beta-D-glucopyranoside + H2O	-	Rattus norvegicus	4-methylumbelliferone + beta-D-glucopyranose	-	?

Synonyms

Synonyms	Comment	Organism
Gcase	-	Rattus norvegicus
glucocerebrosidase	-	Rattus norvegicus

General Information

General Information	Comment	Organism
malfunction	enzyme enzymatic activity is involved in the development of Parkinson's disease symptoms	Rattus norvegicus

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Release 2023.1 (January 2023)