Literature summary for 3.2.1.45 extracted from

Tekoah, Y.; Tzaban, S.; Kizhner, T.; Hainrichson, M.; Gantman, A.; Golembo, M.; Aviezer, D.; Shaaltiel, Y.
Glycosylation and functionality of recombinant beta-glucocerebrosidase from various production systems (2013), Biosci. Rep., 33, e00071.

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.233	-	glucosylceramide	taliglucerase alfa, at pH 5.5 and 37°C	Homo sapiens
0.234	-	glucosylceramide	imiglucerase, at pH 5.5 and 37°C	Homo sapiens
0.247	-	glucosylceramide	velaglucerase alfa, at pH 5.5 and 37°C	Homo sapiens
1.06	-	4-methylumbelliferyl beta-D-glucopyranoside	taliglucerase alfa, at pH 5.5 and 37°C	Homo sapiens
1.107	-	4-methylumbelliferyl beta-D-glucopyranoside	velaglucerase alfa, at pH 5.5 and 37°C	Homo sapiens
1.127	-	4-methylumbelliferyl beta-D-glucopyranoside	imiglucerase, at pH 5.5 and 37°C	Homo sapiens
2.331	-	4-nitrophenyl beta-D-glucopyranoside	velaglucerase alfa, at pH 5.5 and 37°C	Homo sapiens
2.415	-	4-nitrophenyl beta-D-glucopyranoside	imiglucerase, at pH 5.5 and 37°C	Homo sapiens
2.592	-	4-nitrophenyl beta-D-glucopyranoside	taliglucerase alfa, at pH 5.5 and 37°C	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
glucocerebroside + H2O	Homo sapiens	-	ceramide + D-glucose	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-methylumbelliferyl beta-D-glucopyranoside + H2O	-	Homo sapiens	4-methylumbelliferone + beta-D-glucopyranose	-	?
4-nitrophenyl beta-D-glucopyranoside + H2O	-	Homo sapiens	4-nitrophenol + D-glucopyranose	-	?
glucocerebroside + H2O	-	Homo sapiens	ceramide + D-glucose	-	?
glucosylceramide + H2O	-	Homo sapiens	beta-D-glucose + ceramide	-	?

Synonyms

Synonyms	Comment	Organism
beta-glucocerebrosidase	-	Homo sapiens
Imiglucerase	-	Homo sapiens
taliglucerase alfa	-	Homo sapiens
velaglucerase alfa	-	Homo sapiens

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Release 2023.1 (January 2023)