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Literature summary for 3.2.1.45 extracted from

  • Schoenemann, W.; Gallienne, E.; Compain, P.; Ikeda, K.; Asano, N.; Martin, O.R.
    Synthesis of new beta-1-C-alkylated imino-L-iditols: A comparative study of their activity as beta-glucocerebrosidase inhibitors (2010), Bioorg. Med. Chem., 18, 2645-2650.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
alpha-1-C-butyl-1-deoxynojirimycin
-
Homo sapiens
alpha-1-C-hexyl-1-deoxyimino-D-xylitol
-
Homo sapiens
alpha-1-C-hexyl-1-deoxynojirimycin
-
Homo sapiens
alpha-1-C-nonyl-1-deoxyimino-D-xylitol strong inhibitor Homo sapiens
alpha-1-C-propyl-1-deoxyimino-D-xylitol
-
Homo sapiens
alpha-1-C-propyl-1-deoxynojirimycin
-
Homo sapiens
beta-1-C-butyl-1,5-dideoxy-1,5-imino-L-iditol
-
Homo sapiens
beta-1-C-hexyl-1,5-dideoxy-1,5-imino-L-iditol
-
Homo sapiens
beta-1-C-propyl-1,5-dideoxy-1,5-imino-L-iditol
-
Homo sapiens
additional information not inhibited by beta-1-C-(2,3-dihydroxypropyl)-1,5-dideoxy-1,5-imino-L-iditol Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glucosylceramide + H2O Homo sapiens
-
beta-D-glucose + ceramide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl beta-D-glucopyranoside + H2O
-
Homo sapiens 4-nitrophenol + D-glucopyranose
-
?
glucosylceramide + H2O
-
Homo sapiens beta-D-glucose + ceramide
-
?

Synonyms

Synonyms Comment Organism
beta-glucocerebrosidase
-
Homo sapiens
Ceredase commercial preparation Homo sapiens
Gcase
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.2
-
alpha-1-C-nonyl-1-deoxyimino-D-xylitol in 0.15 M citrate-phosphate buffer (pH 5.5), 1% sodium taurocholate/Triton X-100, at 37°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000019
-
in 0.15 M citrate-phosphate buffer (pH 5.5), 1% sodium taurocholate/Triton X-100, at 37°C Homo sapiens alpha-1-C-hexyl-1-deoxyimino-D-xylitol
0.00056
-
in 0.15 M citrate-phosphate buffer (pH 5.5), 1% sodium taurocholate/Triton X-100, at 37°C Homo sapiens alpha-1-C-propyl-1-deoxyimino-D-xylitol
0.0042
-
in 0.15 M citrate-phosphate buffer (pH 5.5), 1% sodium taurocholate/Triton X-100, at 37°C Homo sapiens alpha-1-C-hexyl-1-deoxynojirimycin
0.043
-
in 0.15 M citrate-phosphate buffer (pH 5.5), 1% sodium taurocholate/Triton X-100, at 37°C Homo sapiens beta-1-C-hexyl-1,5-dideoxy-1,5-imino-L-iditol
0.1
-
in 0.15 M citrate-phosphate buffer (pH 5.5), 1% sodium taurocholate/Triton X-100, at 37°C Homo sapiens alpha-1-C-butyl-1-deoxynojirimycin
0.147
-
in 0.15 M citrate-phosphate buffer (pH 5.5), 1% sodium taurocholate/Triton X-100, at 37°C Homo sapiens beta-1-C-butyl-1,5-dideoxy-1,5-imino-L-iditol
0.4
-
in 0.15 M citrate-phosphate buffer (pH 5.5), 1% sodium taurocholate/Triton X-100, at 37°C Homo sapiens alpha-1-C-propyl-1-deoxynojirimycin
0.487
-
in 0.15 M citrate-phosphate buffer (pH 5.5), 1% sodium taurocholate/Triton X-100, at 37°C Homo sapiens beta-1-C-propyl-1,5-dideoxy-1,5-imino-L-iditol