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Literature summary for 3.2.1.45 extracted from

  • Huang, W.; Zheng, W.; Urban, D.J.; Inglese, J.; Sidransky, E.; Austin, C.P.; Thomas, C.J.
    N4-phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease (2007), Bioorg. Med. Chem. Lett., 17, 5783-5789.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
1-([4-[(2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)-3-phenylpropan-2-ol
-
Homo sapiens
1-([4-[(2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)propan-2-ol
-
Homo sapiens
2,2'-([4-[(5-chloro-2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]imino)diethanol
-
Homo sapiens
2-(4-(5-chloro-2-methoxyphenylamino)-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-ylamino)ethanol
-
Homo sapiens
2-([4-(3,3-difluoropyrrolidin-1-yl)-6-[(2-methoxyphenyl)amino]-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-(benzylamino)-6-[(2-methoxyphenyl)amino]-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-(butylamino)-6-[(2-methoxyphenyl)amino]-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-azetidin-1-yl-6-[(2-methoxyphenyl)amino]-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-[(2,4-dimethoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-[(2,5-dimethoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-[(2-chlorophenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-[(2-ethoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-[(2-hydroxyethyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)benzamide
-
Homo sapiens
2-([4-[(2-hydroxyethyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)phenol
-
Homo sapiens
2-([4-[(2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)acetamide
-
Homo sapiens
2-([4-[(2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-[(2-methylphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-[(2-nitrophenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-[(2-phenoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-[(2-tert-butoxy-5-chlorophenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-[(2-tert-butoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-[(3-chlorophenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-[(3-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-[(3-methylphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-[(4-chlorophenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-[(4-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-[(4-methylphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-[(5-benzyl-2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-[(5-chloro-2-ethoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-[(5-chloro-2-methoxyphenyl)amino]-6-(diethylamino)-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-[(5-chloro-2-methoxyphenyl)amino]-6-azepan-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-[(5-chloro-2-methoxyphenyl)amino]-6-morpholin-4-yl-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-([4-[(5-chloro-2-methoxyphenyl)amino]-6-piperidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
-
Homo sapiens
2-[(4-pyrrolidin-1-yl-6-[[2-(trifluoromethoxy)phenyl]amino]-1,3,5-triazin-2-yl)amino]ethanol
-
Homo sapiens
2-[(4-[[2-(benzyloxy)phenyl]amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)amino]ethanol
-
Homo sapiens
2-[(4-[[2-(methylsulfanyl)phenyl]amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)amino]ethanol
-
Homo sapiens
2-[(4-[[2-methoxy-5-(trifluoromethyl)phenyl]amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)amino]ethanol
-
Homo sapiens
2-[(4-[[5-chloro-2-(1-methylethoxy)phenyl]amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)amino]ethanol
-
Homo sapiens
2-[[4-(phenylamino)-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino]ethanol
-
Homo sapiens
4-([4-[(2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)butan-1-ol
-
Homo sapiens
4-benzyl-2-([4-[(2-hydroxyethyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)phenol
-
Homo sapiens
4-chloro-2-([4-[(2-hydroxyethyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)phenol
-
Homo sapiens
methyl ([4-[(2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)acetate
-
Homo sapiens
N-(4-methyl-2-morpholinoquinolin-6-yl)cyclohexanecarboxamide
-
Homo sapiens
N-(5-chloro-2-methoxyphenyl)-6-pyrrolidin-1-yl-1,3,5-triazine-2,4-diamine
-
Homo sapiens
N-(5-chloro-2-methoxyphenyl)-N'-(2-methoxyethyl)-6-pyrrolidin-1-yl-1,3,5-triazine-2,4-diamine
-
Homo sapiens
N-(5-chloro-2-methoxyphenyl)-N'-(furan-2-ylmethyl)-6-pyrrolidin-1-yl-1,3,5-triazine-2,4-diamine
-
Homo sapiens
N-(5-ethyl-1,3,4-thiadiazol-2-yl)-4-(phenylsulfonamido)benzamide
-
Homo sapiens
N-benzyl-N'-(5-chloro-2-methoxyphenyl)-6-pyrrolidin-1-yl-1,3,5-triazine-2,4-diamine
-
Homo sapiens
N-butyl-deoxynojirimycin Miglustat Homo sapiens
N-butyl-N'-(5-chloro-2-methoxyphenyl)-6-pyrrolidin-1-yl-1,3,5-triazine-2,4-diamine
-
Homo sapiens
N-[2-([4-[(2-hydroxyethyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)phenyl]acetamide
-
Homo sapiens
N-[2-([4-[(2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethyl]acetamide
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
glucocerebrosidase
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000031
-
-
Homo sapiens N-(4-methyl-2-morpholinoquinolin-6-yl)cyclohexanecarboxamide
0.00007
-
-
Homo sapiens N-(5-ethyl-1,3,4-thiadiazol-2-yl)-4-(phenylsulfonamido)benzamide
0.00033
-
-
Homo sapiens 2-([4-[(2-tert-butoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
0.00037
-
-
Homo sapiens 4-benzyl-2-([4-[(2-hydroxyethyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)phenol
0.0007
-
-
Homo sapiens 2-(4-(5-chloro-2-methoxyphenylamino)-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-ylamino)ethanol
0.00073
-
-
Homo sapiens 4-chloro-2-([4-[(2-hydroxyethyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)phenol
0.00077
-
-
Homo sapiens 2-([4-[(2-ethoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
0.00096
-
-
Homo sapiens 2-([4-[(5-chloro-2-ethoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
0.00104
-
-
Homo sapiens 2-([4-[(2-tert-butoxy-5-chlorophenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
0.00108
-
-
Homo sapiens 2-([4-[(2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
0.00153
-
-
Homo sapiens 2-([4-[(2,5-dimethoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
0.002
-
-
Homo sapiens 2-([4-[(2-hydroxyethyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)phenol
0.00222
-
-
Homo sapiens 2-([4-[(5-benzyl-2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
0.00231
-
-
Homo sapiens 2-([4-azetidin-1-yl-6-[(2-methoxyphenyl)amino]-1,3,5-triazin-2-yl]amino)ethanol
0.00239
-
-
Homo sapiens 2-[(4-[[2-(methylsulfanyl)phenyl]amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)amino]ethanol
0.00265
-
-
Homo sapiens 2-[(4-[[2-methoxy-5-(trifluoromethyl)phenyl]amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)amino]ethanol
0.00334
-
-
Homo sapiens 2-[(4-pyrrolidin-1-yl-6-[[2-(trifluoromethoxy)phenyl]amino]-1,3,5-triazin-2-yl)amino]ethanol
0.00344
-
-
Homo sapiens 2-[(4-[[5-chloro-2-(1-methylethoxy)phenyl]amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)amino]ethanol
0.00394
-
-
Homo sapiens 2-([4-[(2-methylphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
0.0049
-
-
Homo sapiens 2-([4-[(2,4-dimethoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
0.0061
-
-
Homo sapiens 2-([4-(butylamino)-6-[(2-methoxyphenyl)amino]-1,3,5-triazin-2-yl]amino)ethanol
0.00619
-
-
Homo sapiens 2-([4-[(3-methylphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
0.00634
-
-
Homo sapiens 2-([4-[(4-chlorophenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
0.00669
-
-
Homo sapiens 2-([4-[(3-chlorophenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
0.0068
-
-
Homo sapiens 1-([4-[(2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)-3-phenylpropan-2-ol
0.0075
-
-
Homo sapiens 2-([4-(3,3-difluoropyrrolidin-1-yl)-6-[(2-methoxyphenyl)amino]-1,3,5-triazin-2-yl]amino)ethanol
0.00777
-
-
Homo sapiens N-butyl-N'-(5-chloro-2-methoxyphenyl)-6-pyrrolidin-1-yl-1,3,5-triazine-2,4-diamine
0.00825
-
-
Homo sapiens 2-([4-[(3-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
0.0088
-
-
Homo sapiens 2-([4-[(4-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
0.01004
-
-
Homo sapiens 2-([4-[(4-methylphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
0.01213
-
-
Homo sapiens 2-([4-[(5-chloro-2-methoxyphenyl)amino]-6-morpholin-4-yl-1,3,5-triazin-2-yl]amino)ethanol
0.01647
-
-
Homo sapiens 2-[[4-(phenylamino)-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino]ethanol
0.0188
-
-
Homo sapiens 2-([4-(benzylamino)-6-[(2-methoxyphenyl)amino]-1,3,5-triazin-2-yl]amino)ethanol
0.0207
-
-
Homo sapiens 1-([4-[(2-methoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)propan-2-ol
0.02167
-
-
Homo sapiens 2-[(4-[[2-(benzyloxy)phenyl]amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)amino]ethanol
0.02897
-
-
Homo sapiens 2-([4-[(2-chlorophenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
0.0311
-
-
Homo sapiens 2-([4-[(5-chloro-2-methoxyphenyl)amino]-6-piperidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol
0.0314
-
-
Homo sapiens 2-([4-[(2-phenoxyphenyl)amino]-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl]amino)ethanol