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Literature summary for 3.2.1.45 extracted from

  • Zhu, Y.; Li, X.; Schuchman, E.H.; Desnick, R.J.; Cheng, S.H.
    Dexamethasone-mediated up-regulation of the mannose receptor improves the delivery of recombinant glucocerebrosidase to Gaucher macrophages (2004), J. Pharmacol. Exp. Ther., 308, 705-711.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
dexamethasone the pretreatment with dexamethasone has the effect of selectively increasing the uptake of wild-type and recombinant enzymes by the macrophages but not by the liver sinusoidal endothelial cells or hepatocyte cells in vitro, the dexamethasone pre-treatment increases the uptake of enzyme by kupffer cells and by splenic macrophages in vivo. Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl-beta-D-glucopyranoside + H2O
-
Homo sapiens 4-methylumbelliferone + beta-D-glucose
-
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