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Literature summary for 3.2.1.45 extracted from

  • Fabbro, D.; Grabowski, G.A.
    Human acid beta-glucosidase. Use of inhibitory and activating monoclonal antibodies to investigate the enzyme's catalytic mechanism and saposin A and C binding sites (1991), J. Biol. Chem., 266, 15021-15027.
    View publication on PubMed
Search for more literature for 3.2.1.45

Activating Compound

Activating Compound Comment Organism Structure
monoclonal antibody no. 122 mimicking the effect of saposin C Homo sapiens
saposin-A sphingolipid activator protein, only in synergy with saposin-C Homo sapiens
saposin-C sphingolipid activator protein, SAP-2 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(1R,2R,3S,4S,5R,6S)-7-oxabicyclo[4.1.0]heptane-2,3,4,5-tetrol
-
 Homo sapiens
monoclonal antibodies 100% inhibition with F1 and F2, 60% inhibition with no. 61 Homo sapiens
N-dodecyl-1-deoxynojirimycin
-
 Homo sapiens
N-tetradecyl-1-deoxynojirimycin
-
 Homo sapiens
N-tetradecylglycosylamine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glucocerebroside + H2O Homo sapiens
-
 glucose + ceramide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl-beta-D-glucopyranoside + H2O
-
 Homo sapiens methylumbelliferone + glucose
-
 ?
glucocerebroside + H2O
-
 Homo sapiens glucose + ceramide
-
 ?