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Literature summary for 3.2.1.45 extracted from

  • Aerts, J.M.; Sa Miranda, M.C.; Brouwer-Kelder, E.M.; Van Weely, S.; Barranger, J.A.; Tager, J.M.
    Conditions affecting the activity of glucocerebrosidase purified from spleens of control subjects and patients with type 1 Gaucher disease (1990), Biochim. Biophys. Acta, 1041, 55-63.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
phosphatidylserine
-
Homo sapiens
saposin-C sphingolipid activator protein, SAP-2 Homo sapiens
sodium taurocholate
-
Homo sapiens

Application

Application Comment Organism
medicine Gaucher disease, sphingolipoidose Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glucocerebroside + H2O Homo sapiens
-
glucose + ceramide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
normal and Gaucher disease enzyme
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
spleen
-
Homo sapiens
-

Storage Stability

Storage Stability Organism
-20°C, pH 6, 90% ethylene glycol, 20 days, no loss of activity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl-beta-D-glucopyranoside + H2O
-
Homo sapiens methylumbelliferone + glucose
-
?
glucocerebroside + H2O
-
Homo sapiens glucose + ceramide
-
?