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Literature summary for 3.2.1.36 extracted from

  • Meyer, K.; Rapport, M.M.
    Hyaluronidases (1952), Adv. Enzymol. Relat. Subj. Biochem., 13, 199-236.
    View publication on PubMed

Application

Application Comment Organism
medicine increasing absorption of fluids in dermal clysis, increasing diffusion of injected substances Streptococcus sp.

Inhibitors

Inhibitors Comment Organism Structure
Cu2+
-
Streptococcus agalactiae
Fe2+
-
Streptococcus agalactiae
polymer from gentisic acid
-
Streptococcus agalactiae
serum protein from human, inhibition by a true antibody Streptococcus sp.
Zn2+
-
Streptococcus agalactiae

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secreted from cell culture Staphylococcus aureus
-
-
extracellular secreted from cell culture Schistosoma mansoni
-
-
extracellular secreted from cell culture Streptococcus agalactiae
-
-
extracellular secreted from cell culture Clostridium welchii
-
-
extracellular secreted from cell culture Streptococcus sp.
-
-
extracellular secreted from cell culture Treponema pallidum
-
-
extracellular secreted from cell culture Pneumococcus sp.
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hyaluronic acid + H2O Staphylococcus aureus
-
?
-
?
hyaluronic acid + H2O Schistosoma mansoni
-
?
-
?
hyaluronic acid + H2O Streptococcus agalactiae
-
?
-
?
hyaluronic acid + H2O Streptococcus sp.
-
?
-
?
hyaluronic acid + H2O Treponema pallidum
-
?
-
?
hyaluronic acid + H2O Pneumococcus sp.
-
?
-
?
hyaluronic acid + H2O Streptococcus sp. decapsulation of mucoid strains ?
-
?
hyaluronic acid + H2O Clostridium welchii further hydrolysis of the end-products from bovine testicular enzyme ?
-
?
hyaluronic acid + H2O Streptococcus sp. further hydrolysis of the end-products from bovine testicular enzyme ?
-
?
hyaluronic acid + H2O Streptococcus sp. spreading factor for dermonecrosis ?
-
?

Organism

Organism UniProt Comment Textmining
Clostridium welchii
-
-
-
Pneumococcus sp.
-
-
-
Schistosoma mansoni
-
-
-
Staphylococcus aureus
-
enzyme acts synergistically with vaccinia virus, greatly enhancing the infectivitiy of the virus
-
Streptococcus agalactiae
-
-
-
Streptococcus sp.
-
strains A and C
-
Treponema pallidum
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
Staphylococcus aureus
-
cell culture
-
Schistosoma mansoni
-
cell culture
-
Streptococcus agalactiae
-
cell culture
-
Clostridium welchii
-
cell culture
-
Streptococcus sp.
-
cell culture
-
Treponema pallidum
-
cell culture
-
Pneumococcus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
chondroitin sulfate A + H2O
-
Streptococcus agalactiae oligosaccharides + ?
-
?
hyaluronic acid + H2O
-
Staphylococcus aureus ?
-
?
hyaluronic acid + H2O
-
Schistosoma mansoni ?
-
?
hyaluronic acid + H2O
-
Streptococcus agalactiae ?
-
?
hyaluronic acid + H2O
-
Streptococcus sp. ?
-
?
hyaluronic acid + H2O
-
Treponema pallidum ?
-
?
hyaluronic acid + H2O
-
Pneumococcus sp. ?
-
?
hyaluronic acid + H2O decapsulation of mucoid strains Streptococcus sp. ?
-
?
hyaluronic acid + H2O further hydrolysis of the end-products from bovine testicular enzyme Clostridium welchii ?
-
?
hyaluronic acid + H2O further hydrolysis of the end-products from bovine testicular enzyme Streptococcus sp. ?
-
?
hyaluronic acid + H2O spreading factor for dermonecrosis Streptococcus sp. ?
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
60
-
nearly completely destroyed Pneumococcus sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
-
Staphylococcus aureus
6
-
-
Clostridium welchii