Literature summary for 3.2.1.35 extracted from

Srivastav, A.; Chandra, A.; Singh, M.; Jamal, F.; Rastogi, P.; Rajendran, S.M.; Bansode, F.W.; Lakshmi, V.
Inhibition of hyaluronidase activity of human and rat spermatozoa in vitro and antispermatogenic activity in rats in vivo by Terminalia chebula, a flavonoid rich plant (2010), Reprod. Toxicol., 29, 214-224.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	the residual activities normalized to 100% at 0 concentrations of Terminalia chebula extract are reduced to 84% at 0.1 mg/ml, 68% at 0.5 mg/ml, 57% at 1 mg/ml, 26% at 1.5 mg/ml, 20% at 3 mg/ml, and 7% at 30 mg/ml	Homo sapiens
additional information	the residual activities normalized to 100% at 0 concentrations of Terminalia chebula extract are reduced to 88% at 0.1 mg/ml, 78% at 0.5 mg/ml, 58 at 1 mg/ml, 49% at 1.5 mg/ml, 29% at 3 mg/ml, and 15% at 30 mg/ml	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
spermatozoon	-	Homo sapiens	-
spermatozoon	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
hyaluronan + 2 H2O	-	Homo sapiens	N-acetyl-beta-D-glucosamine + D-glucuronate + ?	-	?
hyaluronan + 2 H2O	-	Rattus norvegicus	N-acetyl-beta-D-glucosamine + D-glucuronate + ?	-	?

Synonyms

Synonyms	Comment	Organism
HAase	-	Homo sapiens
HAase	-	Rattus norvegicus
hyaluronidase	-	Homo sapiens
hyaluronidase	-	Rattus norvegicus

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Release 2023.1 (January 2023)