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Literature summary for 3.2.1.35 extracted from

  • Iwanaga, A.; Kusano, G.; Warashina, T.; Miyase, T.
    Hyaluronidase inhibitors from "Cimicifugae Rhizoma" (a mixture of the rhizomes of Cimicifuga dahurica and C. heracleifolia) (2010), J. Nat. Prod., 73, 573-578.
    View publication on PubMed
Search for more literature for 3.2.1.35

Inhibitors

Inhibitors Comment Organism Structure
(2R,3S)-2-(3,4-dihydroxybenzyl)-2-hydroxy-3-[[(2E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoyl]oxy]butanedioic acid
-
 Bos taurus
(2R,3S)-2-(3,4-dihydroxybenzyl)-2-hydroxy-3-[[(2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxy]butanedioic acid
-
 Bos taurus
(2R,3S)-2-(3,4-dihydroxybenzyl)-2-hydroxy-3-[[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]oxy]butanedioic acid
-
 Bos taurus
(2R,3S)-2-hydroxy-2-(4-hydroxybenzyl)-3-[[(2E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoyl]oxy]butanedioic acid
-
 Bos taurus
(2R,3S)-2-hydroxy-2-(4-hydroxybenzyl)-3-[[(2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxy]butanedioic acid
-
 Bos taurus
(2R,3S)-3-[[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-2-hydroxy-2-(4-hydroxybenzyl)butanedioic acid
-
 Bos taurus
(2R,3S)-3-[[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]oxy]-2-hydroxy-2-(4-hydroxybenzyl)butanedioic acid
-
 Bos taurus
cimicifugic acid H
-
 Bos taurus
cimicifugic acid I
-
 Bos taurus
cimicifugic acid J
-
 Bos taurus
fukinolic acid
-
 Bos taurus
rosmarinic acid
-
 Bos taurus
shomaside A
-
 Bos taurus
shomaside B
-
 Bos taurus
shomaside C
-
 Bos taurus
shomaside D
-
 Bos taurus
shomaside E
-
 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
chondroitin sulfate A + H2O
-
 Bos taurus oligosaccharides + ?
-
 ?
hyaluronan + 2 H2O
-
 Bos taurus N-acetyl-beta-D-glucosamine + D-glucuronate + ?
-
 ?

Synonyms

Synonyms Comment Organism
hyaluronidase
-
 Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.082
-
 in 0.1 mM acetate buffer (pH 3.5), at 37°C Bos taurus (2R,3S)-2-(3,4-dihydroxybenzyl)-2-hydroxy-3-[[(2E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoyl]oxy]butanedioic acid
0.092
-
 in 0.1 mM acetate buffer (pH 3.5), at 37°C Bos taurus (2R,3S)-2-hydroxy-2-(4-hydroxybenzyl)-3-[[(2E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoyl]oxy]butanedioic acid
0.112
-
 in 0.1 mM acetate buffer (pH 3.5), at 37°C Bos taurus (2R,3S)-2-(3,4-dihydroxybenzyl)-2-hydroxy-3-[[(2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxy]butanedioic acid
0.12
-
 in 0.1 mM acetate buffer (pH 3.5), at 37°C Bos taurus (2R,3S)-2-hydroxy-2-(4-hydroxybenzyl)-3-[[(2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxy]butanedioic acid
0.138
-
 in 0.1 mM acetate buffer (pH 3.5), at 37°C Bos taurus (2R,3S)-3-[[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]oxy]-2-hydroxy-2-(4-hydroxybenzyl)butanedioic acid
0.143
-
 in 0.1 mM acetate buffer (pH 3.5), at 37°C Bos taurus cimicifugic acid I
0.144
-
 in 0.1 mM acetate buffer (pH 3.5), at 37°C Bos taurus fukinolic acid
0.153
-
 in 0.1 mM acetate buffer (pH 3.5), at 37°C Bos taurus (2R,3S)-3-[[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-2-hydroxy-2-(4-hydroxybenzyl)butanedioic acid
0.193
-
 in 0.1 mM acetate buffer (pH 3.5), at 37°C Bos taurus cimicifugic acid J
0.251
-
 in 0.1 mM acetate buffer (pH 3.5), at 37°C Bos taurus (2R,3S)-2-(3,4-dihydroxybenzyl)-2-hydroxy-3-[[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]oxy]butanedioic acid
0.43
-
 in 0.1 mM acetate buffer (pH 3.5), at 37°C Bos taurus shomaside B
0.525
-
 in 0.1 mM acetate buffer (pH 3.5), at 37°C Bos taurus cimicifugic acid H
0.545
-
 in 0.1 mM acetate buffer (pH 3.5), at 37°C Bos taurus rosmarinic acid
0.573
-
 in 0.1 mM acetate buffer (pH 3.5), at 37°C Bos taurus shomaside A
0.658
-
 IC50 above 0.658 mM, in 0.1 mM acetate buffer (pH 3.5), at 37°C Bos taurus shomaside D
0.663
-
 in 0.1 mM acetate buffer (pH 3.5), at 37°C Bos taurus shomaside C
0.79
-
 IC50 above 0.79 mM, in 0.1 mM acetate buffer (pH 3.5), at 37°C Bos taurus shomaside E