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Literature summary for 3.2.1.35 extracted from
- Designed human serum hyaluronidase 1 variant, HYAL1DeltaL, exhibits activity up to pH 5.9 (2009), J. Biol. Chem., 284, 19173-19177.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli and in Xenopus laevis oocytes | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q12794 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| serum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| hyaluronan + 2 H2O | - |
Homo sapiens | N-acetyl-beta-D-glucosamine + D-glucuronate + ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HYAL1 | - |
Homo sapiens |
| hyaluronidase 1 | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | - |
wild type enzyme | Homo sapiens |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 5.1 | 5.9 | human serum hyaluronidase 1 is inactive above pH 5.1, while human serum hyaluronidase 1 variant HYAL1DELTAL exhibits activity up to pH 5.9 | Homo sapiens |
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Release 2023.1 (January 2023)
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