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Literature summary for 3.2.1.35 extracted from
- Xenopus kidney hyaluronidase-1 (XKH1), a novel type of membrane-bound hyaluronidase, solely degrades hyaluronan at neutral pH (2001), FEBS Lett., 505, 213-216.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | activity is optimal at physiological salt concentrations | Xenopus laevis |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| DNA and amino acid sequence determination and analysis, expressed by injection of mRNA in frog oocytes on the outer surface of the cell membrane | Xenopus laevis |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | bound | Xenopus laevis | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Xenopus laevis | Q8UVT7 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| no modification | - |
Xenopus laevis |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| hyaluronic acid hexasaccharide + H2O = hyaluronic acid disaccharide + hyaluronic acid tetrasaccharide | also hydrolyses 1,4-beta-D-glycosidic linkages between N-acetyl-galactosamine or N-acetylgalactosamine sulfate and glucuronic acid in chondroitin, chondroitin 4- and 6-sulfates, and dermatan | Xenopus laevis |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Xenopus laevis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| hyaluronan + H2O | complete degradation, absolutely specific for | Xenopus laevis | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| chondroitinase | - |
Xenopus laevis |
| chondroitinase I | - |
Xenopus laevis |
| hyaluronidase | - |
Xenopus laevis |
| hyaluronidase-1 | - |
Xenopus laevis |
| hyaluronoglucosidase | - |
Xenopus laevis |
| XKH1 | - |
Xenopus laevis |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
narrow activity range in the slightly acidic and neutral pH, inactive below pH 5.4 | Xenopus laevis |
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