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Literature summary for 3.2.1.35 extracted from
- Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase (2001), Biochem. Biophys. Res. Commun., 283, 634-640.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene mgea5, DNA sequence determination and analysis, genomic organization on chromosome 10, 2 splice variants, one missing a putative acetyltransferase domain of the enzyme | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoskeleton | 130 kDa enzyme form | Homo sapiens | 5856 | - |
| cytosol | 130 kDa enzyme form | Homo sapiens | 5829 | - |
| membrane | 130 kDa enzyme form | Homo sapiens | 16020 | - |
| nucleus | 75 kDa enzyme form | Homo sapiens | 5634 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 75000 | - |
x * 130000, enzyme form 1, SDS-PAGE, x * 75000, enzyme form 2, SDS-PAGE | Homo sapiens |
| 130000 | - |
x * 130000, enzyme form 1, SDS-PAGE, x * 75000, enzyme form 2, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O60502 | gene mgea5, bifunctional enzyme possessing hyaluronidase and beta-N-acetylglucoaminidase activities | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | posttranslational modification of a larger protein of 130 kDa to a 75 kDa form | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocytoma cell | primary pilocytic | Homo sapiens | - |
| brain | - |
Homo sapiens | - |
| colon | - |
Homo sapiens | - |
| gall bladder | - |
Homo sapiens | - |
| heart | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| lung carcinoma cell | - |
Homo sapiens | - |
| meningioma cell | - |
Homo sapiens | - |
| additional information | both splice variants of gene mgea5 are ubiquitously expressed in various tissues | Homo sapiens | - |
| placenta | - |
Homo sapiens | - |
| skeletal muscle | - |
Homo sapiens | - |
| stomach | - |
Homo sapiens | - |
| TX3868 cell | glioblastoma cell line | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| hyaluronate + H2O | from umbilical cord | Homo sapiens | N-acetyl-beta-D-glucosamine + D-glucuronate + ? | - |
? |  |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 130000, enzyme form 1, SDS-PAGE, x * 75000, enzyme form 2, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| hyaluronidase | - |
Homo sapiens |
| MGEA5 | - |
Homo sapiens |
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