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Literature summary for 3.2.1.35 extracted from

  • Toida, T.; Ogita, Y.; Suzuki, A.; Toyoda, H.; Imanari, T.
    Inhibition of hyaluronidase by fully O-sulfonated glycosaminoglycans (1999), Arch. Biochem. Biophys., 370, 176-182.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
chondroitin O-sulfate IC50 = 0.00133 mg/ml Homo sapiens
dermatan O-sulfate IC50 = 0.00133 mg/ml Homo sapiens
fully O-sulfonated chondroitin sulfate competitive and noncompetitive mode, 50% inhibition at 0.00135 mg/ml Homo sapiens
fully O-sulfonated dermatan sulfate competitive and noncompetitive mode, 50% inhibition at 0.00133 mg/ml Homo sapiens
fully O-sulfonated heparan sulfate competitive and noncompetitive mode, 50% inhibition at 0.00128 mg/ml Homo sapiens
fully O-sulfonated heparin 50% inhibition at 0.00114 mg/ml Homo sapiens
fully O-sulfonated hyaluronan 50% inhibition at 0.00078 mg/ml Homo sapiens
heparan O-sulfate IC50 = 0.00128 mg/ml Homo sapiens
heparin IC50 = 0.00114 mg/ml, non-competitive inhibition; noncompetitive Homo sapiens
heparin O-sulfate IC50 = 0.00114 mg/ml, competitive and non-competitive inhibitory effects Homo sapiens
hyaluronan O-sulfate IC50 = 0.00078 mg/ml Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hyaluronic acid + H2O Homo sapiens involved in inflammatory reactions, exists as inactive form activated by metal ions ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
hyaluronic acid hexasaccharide + H2O = hyaluronic acid disaccharide + hyaluronic acid tetrasaccharide also hydrolyses 1,4-beta-D-glycosidic linkages between N-acetyl-galactosamine or N-acetylgalactosamine sulfate and glucuronic acid in chondroitin, chondroitin 4- and 6-sulfates, and dermatan Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
urine
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
activity measured as turbidicity reducing units Homo sapiens
additional information
-
development of a flow injection assay method using commercial bovine enzyme and fluorometric detection, comparison of fluorogenic reagents, enzyme activity in human urine samples Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hyaluronan + 2 H2O from Streptococcus zooepidemicus Homo sapiens N-acetyl-beta-D-glucosamine + D-glucuronate + ?
-
?
hyaluronan + H2O
-
Homo sapiens tetraoligosaccharides + hexaoligosaccharides after complete digestion ?
hyaluronic acid + H2O involved in inflammatory reactions, exists as inactive form activated by metal ions Homo sapiens ?
-
?
hyaluronic acid + H2O
-
Homo sapiens hyaluronic acid oligomers
-
?

Synonyms

Synonyms Comment Organism
HAase
-
Homo sapiens
hyaluronidase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
assay at Homo sapiens