Inhibitors | Comment | Organism | Structure |
---|---|---|---|
chondroitin O-sulfate | IC50 = 0.00133 mg/ml | Homo sapiens | |
dermatan O-sulfate | IC50 = 0.00133 mg/ml | Homo sapiens | |
fully O-sulfonated chondroitin sulfate | competitive and noncompetitive mode, 50% inhibition at 0.00135 mg/ml | Homo sapiens | |
fully O-sulfonated dermatan sulfate | competitive and noncompetitive mode, 50% inhibition at 0.00133 mg/ml | Homo sapiens | |
fully O-sulfonated heparan sulfate | competitive and noncompetitive mode, 50% inhibition at 0.00128 mg/ml | Homo sapiens | |
fully O-sulfonated heparin | 50% inhibition at 0.00114 mg/ml | Homo sapiens | |
fully O-sulfonated hyaluronan | 50% inhibition at 0.00078 mg/ml | Homo sapiens | |
heparan O-sulfate | IC50 = 0.00128 mg/ml | Homo sapiens | |
heparin | IC50 = 0.00114 mg/ml, non-competitive inhibition; noncompetitive | Homo sapiens | |
heparin O-sulfate | IC50 = 0.00114 mg/ml, competitive and non-competitive inhibitory effects | Homo sapiens | |
hyaluronan O-sulfate | IC50 = 0.00078 mg/ml | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hyaluronic acid + H2O | Homo sapiens | involved in inflammatory reactions, exists as inactive form activated by metal ions | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
hyaluronic acid hexasaccharide + H2O = hyaluronic acid disaccharide + hyaluronic acid tetrasaccharide | also hydrolyses 1,4-beta-D-glycosidic linkages between N-acetyl-galactosamine or N-acetylgalactosamine sulfate and glucuronic acid in chondroitin, chondroitin 4- and 6-sulfates, and dermatan | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
urine | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activity measured as turbidicity reducing units | Homo sapiens |
additional information | - |
development of a flow injection assay method using commercial bovine enzyme and fluorometric detection, comparison of fluorogenic reagents, enzyme activity in human urine samples | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hyaluronan + 2 H2O | from Streptococcus zooepidemicus | Homo sapiens | N-acetyl-beta-D-glucosamine + D-glucuronate + ? | - |
? | |
hyaluronan + H2O | - |
Homo sapiens | tetraoligosaccharides + hexaoligosaccharides | after complete digestion | ? | |
hyaluronic acid + H2O | involved in inflammatory reactions, exists as inactive form activated by metal ions | Homo sapiens | ? | - |
? | |
hyaluronic acid + H2O | - |
Homo sapiens | hyaluronic acid oligomers | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HAase | - |
Homo sapiens |
hyaluronidase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5 | - |
assay at | Homo sapiens |