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Literature summary for 3.2.1.31 extracted from
- Interindividual variability in expression and activity of human beta-glucuronidase in liver and kidney: consequences for drug metabolism (1997), J. Pharmacol. Exp. Ther., 281, 914-920.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | a high varability in the expression of beta-Glc in human liver and kidney. Therefore cleavage of drug glucuronides that accumulate during chronic therapy or are used as prodrugs can show a wide interindividual variability in humans, which might result in variable response to drugs | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| estradiol 3-glucuronide | - |
Homo sapiens |  |
| glycyrrhizin | - |
Homo sapiens | |
| paracetamol glucuronide | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.04 | - |
4-methylumbelliferyl-beta-D-glucuronide | enzyme from kidney | Homo sapiens | |
| 1.32 | - |
4-methylumbelliferyl-beta-D-glucuronide | enzyme from liver | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | high varability in the expression | Homo sapiens | - |
| liver | high varability in the expression | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-methylumbelliferyl-beta-D-glucuronide + H2O | - |
Homo sapiens | 4-methylumbelliferone + D-glucuronic acid | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| beta-Gluc | - |
Homo sapiens |
| beta-glucuronidase | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.47 | - |
glycyrrhizin | enzyme from liver | Homo sapiens | |
| 0.57 | - |
glycyrrhizin | enzyme from kidney | Homo sapiens | |
| 0.9 | - |
estradiol 3-glucuronide | enzyme from liver | Homo sapiens | |
| 1.2 | - |
estradiol 3-glucuronide | enzyme from kidney | Homo sapiens | |
| 1.6 | - |
paracetamol glucuronide | enzyme from liver | Homo sapiens | |
| 2 | - |
paracetamol glucuronide | enzyme from kidney | Homo sapiens | |
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Release 2023.1 (January 2023)
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