Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,4-dideoxy-1,4-[[(2S,3S,4R,5R)-2,4,5,6-tetrahydroxy-3-(sulfooxy)hexyl]-(R)-epi-seleniumylidene]-D-arabinitol inner salt | - |
Homo sapiens | |
1,4-dideoxy-1,4-[[(2S,3S,4R,5R)-2,4,5,6-tetrahydroxy-3-(sulfooxy)hexyl]-(R)-epi-sulfoniumylidene]-D-arabinitol inner salt | - |
Homo sapiens | |
1,4-dideoxy-1,4-[[(2S,3S,4R,5R)-2,4,5,6-tetrahydroxy-3-(sulfooxy)hexyl]-(S)-epi-seleniumylidene]-D-arabinitol inner salt | - |
Homo sapiens | |
acarbose | - |
Homo sapiens | |
blintol | - |
Homo sapiens | |
kotalanol | natural inhibitor isolated from the roots and stems of the plant Salacia reticulata | Homo sapiens | |
additional information | structure-activity relationship and stereochemistry of inhibitors, synthesis of chain-extended sulfonium and selenonium salts of 1,4-anhydro-4-thio- or 4-seleno-D-arabinitol, analogues of the naturally occurring glycosidase inhibitor salacinol, by nucleophilic attack at the least hindered carbon atom of 4,6-O-benzylidene-2,5-di-O-p-methoxybenzyl-D-mannitol-1,3-cyclic sulfate by 2,3,5-tri-O-p-methoxybenzyl-1,4-anhydro-4-thio-or 4-seleno-D-arabinitol, giving the sulfonium and selenonium sulfates, respectively, and subsequent deprotection with trifluoroacetic acid, the extended polyhydroxylated aliphatic side chain is incorporated while maintaining the stereochemistry of C-2' and C-3' of salacinol or blintol, overview | Homo sapiens | |
salacinol | natural inhibitor isolated from the roots and stems of the plant Salacia reticulata | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
starch + H2O | Homo sapiens | one of the key intestinal enzymes involved in the breakdown of glucose oligosaccharides in the small intestine | D-glucose + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
small intestine | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl-D-glucopyranoside + H2O | - |
Homo sapiens | 4-nitrophenol + D-glucose | - |
? | |
maltose + H2O | - |
Homo sapiens | 2 D-glucose | - |
? | |
starch + H2O | - |
Homo sapiens | D-glucose + ? | - |
? | |
starch + H2O | one of the key intestinal enzymes involved in the breakdown of glucose oligosaccharides in the small intestine | Homo sapiens | D-glucose + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
maltase glucoamylase | - |
Homo sapiens |
MGA | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00014 | - |
1,4-dideoxy-1,4-[[(2S,3S,4R,5R)-2,4,5,6-tetrahydroxy-3-(sulfooxy)hexyl]-(R)-epi-seleniumylidene]-D-arabinitol inner salt | pH 6.5, 37°C | Homo sapiens | |
0.00065 | - |
1,4-dideoxy-1,4-[[(2S,3S,4R,5R)-2,4,5,6-tetrahydroxy-3-(sulfooxy)hexyl]-(R)-epi-sulfoniumylidene]-D-arabinitol inner salt | pH 6.5, 37°C | Homo sapiens | |
0.0101 | - |
1,4-dideoxy-1,4-[[(2S,3S,4R,5R)-2,4,5,6-tetrahydroxy-3-(sulfooxy)hexyl]-(S)-epi-seleniumylidene]-D-arabinitol inner salt | pH 6.5, 37°C | Homo sapiens |