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Literature summary for 3.2.1.28 extracted from
- Inhibitory effects of validamycin compounds on the termites trehalase (2009), Pestic. Biochem. Physiol., 95, 28-32.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| validamycin A | competitive | Termitoidae |  |
| validamycin B | - |
Termitoidae | |
| validoxylamine A | - |
Termitoidae | |
| validoxylamine B | - |
Termitoidae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics | Termitoidae | |
| 0.031 | - |
trehalose | pH 3.3, 37°C | Termitoidae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trehalose + H2O | Termitoidae | - |
2 D-glucose | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Termitoidae | - |
termites | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trehalose + H2O | - |
Termitoidae | 2 D-glucose | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| trehalase | - |
Termitoidae |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Termitoidae |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | 60 | 40% of maximal activity at 25°C and 60°C | Termitoidae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 3.3 | - |
- |
Termitoidae |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 3 | 4.5 | activity range | Termitoidae |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0032 | - |
validoxylamine A | pH 3.3, 37°C, versus trehalose | Termitoidae | |
| 0.0103 | - |
validoxylamine B | pH 3.3, 37°C, versus trehalose | Termitoidae | |
| 0.27 | - |
validamycin B | pH 3.3, 37°C, versus trehalose | Termitoidae | |
| 0.4 | - |
validamycin A | pH 3.3, 37°C, versus trehalose | Termitoidae | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| additional information | - |
the concentrations of validoxylamine A, validoxylamine B, validamycin A and validamycin B required for 50% inhibition IC50 of termites trehalase are 14.73 mg/l, 20.80 mg/l, 3.17 x 103 mg/l, and 2.24 x 103 mg/l, respectively | Termitoidae | additional information |
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