Literature summary for 3.2.1.24 extracted from

Miyake, K.; Nagai, K.
Inhibition of alpha-mannosidase attenuates endoplasmic reticulum stress-induced neuronal cell death (2009), Neurotoxicology, 30, 144-150.

Search for more literature for 3.2.1.24

Application

Application	Comment	Organism
medicine	inhibition of N-glycan processing in the endoplasmic reticulum attenuates endoplasmic reticulum stress-induced cell death by increasing high-mannose type oligosaccharides that reduce protein aggregation, such as amyloidogenesis	Rattus norvegicus
medicine	inhibition of N-glycan processing in the endoplasmic reticulum attenuates endoplasmic reticulum stressinduced cell death by increasing high-mannose type oligosaccharides that reduce protein aggregation, such as amyloidogenesis	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
1-deoxymannojirimycin	pretreatment with 1-deoxymannojirimycin protectes primary cultured mouse cortical neurons from Amyloid beta1-42 toxicity	Mus musculus
1-deoxymannojirimycin	pretreatment with 100 mM inhibitor 1-deoxymannojirimycin in PC-12 cells significantly attenuates the cytotoxicity by endoplasmic reticulum stressors tunicamycin, thapsigargin, and amyloid bbeta1-42, and reduces caspase-3 activation by tunicamycin and thapsigarin	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
PC-12 cell	-	Rattus norvegicus	-

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Release 2023.1 (January 2023)