Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.24 extracted from

  • Tulsiani, D.R.P.; Hubbard, S.C.; Robbins, P.W.; Touster, O.
    alpha-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates (1982), J. Biol. Chem., 257, 3660-3668.
    View publication on PubMed
Search for more literature for 3.2.1.24

Inhibitors

Inhibitors Comment Organism Structure
Co2+ inhibition of alpha-mannosidases IA and IB Rattus sp.
Cu2+ inhibition of alpha-mannosidases IA, IB and II Rattus sp.
EDTA inhibitory for alpha-mannosidases IA and IB Rattus sp.
methyl-alpha-D-mannopyranoside slight inhibitory for alpha-mannosidases IA and IB Rattus sp.
p-chloromercuribenzenesulfonic acid different inhibition rates for alpha-mannosidases IA, IB and II Rattus sp.
Tris inhibitory for alpha-mannosidases IA and IB Rattus sp.
Zn2+ slight inhibition for alpha-mannosidase IA Rattus sp.

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus 3 isoforms, alpha-mannosidases IA, IB and II Rattus sp. 5794
-
membrane from Golgi-enriched membrane fraction Rattus sp. 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ slight activation for alpha-mannosidase II Rattus sp.
Zn2+ slight activation for alpha-mannosidase II Rattus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Man9-5GlcNAc + 4 H2O Rattus sp. different product composition for alpha-mannosidases IA, IB and II Man5-3GlcNAc + 4 alpha-D-mannopyranose
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus sp.
-
-
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity, chromatography steps Rattus sp.

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Man9-5GlcNAc + 4 H2O different product composition for alpha-mannosidases IA, IB and II Rattus sp. Man5-3GlcNAc + 4 alpha-D-mannopyranose
-
 ?
p-nitrophenyl-alpha-D-mannopyranoside + H2O isoforms mannosidase IB and II Rattus sp. p-nitrophenol + alpha-D-mannopyranose
-
 ?

Synonyms

Synonyms Comment Organism
Golgi alpha-mannosidase II
-
 Rattus sp.
Golgi mannosidase IA
-
 Rattus sp.
Golgi mannosidase IB
-
 Rattus sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
 alpha-mannosidase II with p-nitrophenyl-alpha-D-mannopyranoside as substrate Rattus sp.
5.8
-
 alpha-mannosidase II with Man8GlcNAc as substrate Rattus sp.
6
-
 alpha-mannosidases IA and IB with Man8GlcNAc as substrate Rattus sp.