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Literature summary for 3.2.1.24 extracted from

  • Bischoff, J.; Kornfeld, R.
    Evidence for an alpha-mannosidase in endoplasmatic reticulum of rat liver (1983), J. Biol. Chem., 258, 7907-7910.
    View publication on PubMed
Search for more literature for 3.2.1.24

General Stability

General Stability Organism
extremely labile, stabilized by the presence of 20% glycerol, v/v, 5 mM CoCl2, protease inhibitors Rattus sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.17
-
 p-nitrophenyl-alpha-D-mannopyranoside
-
 Rattus sp.

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Rattus sp. 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-6)]-alpha-D-Man-(1-6)]-beta-D-Man-(1-4)-beta-D-GlcNAc + 6 H2O Rattus sp.
-
 6 alpha-D-mannopyranose + alpha-D-Man-(1-6)-[alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc
-
 ?
Man6GlcNAc + H2O Rattus sp.
-
 alpha-D-mannopyranose + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus sp.
-
-
-

Purification (Commentary)

Purification (Comment) Organism
near homogeneity, doesn't bind to ConA-Sepharose Rattus sp.

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-6)]-alpha-D-Man-(1-6)]-beta-D-Man-(1-4)-beta-D-GlcNAc + 6 H2O
-
 Rattus sp. 6 alpha-D-mannopyranose + alpha-D-Man-(1-6)-[alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc
-
 ?
Man6GlcNAc + H2O
-
 Rattus sp. alpha-D-mannopyranose + ?
-
 ?
p-nitrophenyl-alpha-D-mannopyranoside + H2O responsible for the removal of mannose residues from asparagines-linked high-mannose type oligosaccharides prior to their entry into the Golgi Rattus sp. p-nitrophenol + alpha-D-mannopyranose
-
 ?

Synonyms

Synonyms Comment Organism
ER-alpha-mannosidase
-
 Rattus sp.