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Literature summary for 3.2.1.23 extracted from

  • Broekman, M.L.; Tierney, L.A.; Benn, C.; Chawla, P.; Cha, J.H.; Sena-Esteves, M.
    Mechanisms of distribution of mouse beta-galactosidase in the adult GM1-gangliosidosis brain (2009), Gene Ther., 16, 303-308.
    View publication on PubMed

Application

Application Comment Organism
medicine investigation of the pattern and mechanism of distribution of beta-galactosidase in the adult GM1-galgliosidosis mouse brain upon hippocampla injection of an adeno-associated viral vector encoding beta-galactosidase. Distribution in brain is by diffusion, by axonal transport within the neurons from the site of production, and by cerebrospinal fluid flow in the perivascular space of Virchow-Robin. Evidence of axonal transport of vector-encoded mRNA Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining