Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
alpha-galactosidase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | dendritic cells deficient in alpha-galactosidase-A activity induce vigorous iNKT cell activation in the absence of exogenous antigen. Reconstitution of alpha-galactosidase-A-deficient dendritic cells with recombinant enzyme fully abrogate the iNKT cell response. Lack of alpha-galactosidase-A promote iNKT cell stimulation in vivo. Endogenous iNKT cells in Gla-/- hosts show signs of chronic exposure to self antigens | Mus musculus |