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Literature summary for 3.2.1.22 extracted from

  • Darmoise, A.; Teneberg, S.; Bouzonville, L.; Brady, R.O.; Beck, M.; Kaufmann, S.H.; Winau, F.
    Lysosomal alpha-galactosidase controls the generation of self lipid antigens for natural killer T cells (2010), Immunity, 33, 216-228.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus
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Synonyms

Synonyms Comment Organism
alpha-galactosidase
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Mus musculus

General Information

General Information Comment Organism
malfunction dendritic cells deficient in alpha-galactosidase-A activity induce vigorous iNKT cell activation in the absence of exogenous antigen. Reconstitution of alpha-galactosidase-A-deficient dendritic cells with recombinant enzyme fully abrogate the iNKT cell response. Lack of alpha-galactosidase-A promote iNKT cell stimulation in vivo. Endogenous iNKT cells in Gla-/- hosts show signs of chronic exposure to self antigens Mus musculus