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Literature summary for 3.2.1.22 extracted from
- Hydrolysis of ceramide trihexoside by a specific alpha-galactosidase from human liver (1973), Biochem. J., 133, 1-10.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | absolutely dependent on a mixture of sodium taurocholate and Triton X-100 | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ceramide lactoside | - |
Homo sapiens |  |
| ceramide trihexoside | above 0.13 mM | Homo sapiens | |
| digalactosylceramide | - |
Homo sapiens | |
| Human serum albumin | - |
Homo sapiens | |
| NaCl | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.05 | - |
ceramide trihexoside | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| NaCl | activation | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O | Homo sapiens | - |
lactosyl-N-acylsphingosine + D-galactose | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ceramide trihexoside + H2O | - |
Homo sapiens | ? | - |
? | |
| D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O | - |
Homo sapiens | lactosyl-N-acylsphingosine + D-galactose | - |
? | |
| additional information | methylumbelliferyl alpha-galactosidase and ceramidetrihexoside alpha-galactosidase activity closely associated or identical | Homo sapiens | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 3.5 | - |
ceramide trihexoside | Homo sapiens |
| 4.5 | - |
methylumbelliferyl alpha-galactoside | Homo sapiens |
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Release 2023.1 (January 2023)
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