Literature summary for 3.2.1.21 extracted from

Scherpenzeel, M.; van den Berg, R.; Donker-Koopman, W.; Liskamp, R.; Aerts, J.; Overkleeft, H.; Pieters, R.
Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase (2010), Bioorg. Med. Chem., 18, 267-273.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-deoxynojirimycin	-	Prunus dulcis
4-[4-(cyanomethoxy)phenyl]-4-oxo-N-{3-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]propyl}butanamide	-	Prunus dulcis
N-{3-[4-(cyanomethoxy)benzoyl]benzoyl}propylamido-1-deoxynojirimycin	-	Prunus dulcis

Organism

Organism	UniProt	Comment	Textmining
Prunus dulcis	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
seed	-	Prunus dulcis	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-methylumbelliferyl-beta-D-glucoside + H2O	-	Prunus dulcis	4-methylumbelliferone + beta-D-glucose	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0013	-	N-{3-[4-(cyanomethoxy)benzoyl]benzoyl}propylamido-1-deoxynojirimycin	-	Prunus dulcis
0.0064	-	4-[4-(cyanomethoxy)phenyl]-4-oxo-N-{3-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]propyl}butanamide	-	Prunus dulcis
0.167	-	1-deoxynojirimycin	-	Prunus dulcis

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Release 2023.1 (January 2023)