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Literature summary for 3.2.1.209 extracted from

  • Groisman, B.; Shenkman, M.; Ron, E.; Lederkremer, G.Z.
    Mannose trimming is required for delivery of a glycoprotein from EDEM1 to XTP3-B and to late endoplasmic reticulum-associated degradation steps (2011), J. Biol. Chem., 286, 1292-1300.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.209

Inhibitors

Inhibitors Comment Organism Structure
kifunensine
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum pericentriolar endoplasmic reticulum-derived quality control compartment Homo sapiens 5783
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information when being targeted to endoplasmic reticulum-associated degradation, a misfolded glycoprotein undergoes endoplasmic reticulum mannosidase I-dependent trimming to yield the N-linked oligosaccharide structures Manalpha(1->3)[Manalpha(1->6)[Manalpha(1->3)]Manalpha(1->6)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAcbeta-2-pyridylamine and Manalpha(1->3)[Manalpha(1->6)[Manalpha(1->2)Manalpha(1->3)]Manalpha(1->6)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAcbeta-2-pyridylamine Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ER mannosidase I
-
 Homo sapiens
ERManI
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction endoplasmic reticulum mannosidase I knockdown does not affect binding of an endoplasmic reticulum-associated degradation substrate glycoprotein to EDEM1 Homo sapiens
physiological function endoplasmic reticulum mannosidase I activity is not required for association of H2a with EDEM1 Homo sapiens