Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.209 extracted from

  • Hosokawa, N.; Tremblay, L.O.; Sleno, B.; Kamiya, Y.; Wada, I.; Nagata, K.; Kato, K.; Herscovics, A.
    EDEM1 accelerates the trimming of alpha1,2-linked mannose on the C branch of N-glycans (2010), Glycobiology, 20, 567-575.
    View publication on PubMed
Search for more literature for 3.2.1.209

Protein Variants

Protein Variants Comment Organism
E220Q the mutant contains a conserved acidic amino acid mutation that abolishes alpha1,2-mannosidase enzyme activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha1-antitrypsin null (Hong Kong) + H2O
-
 Homo sapiens ? + D-mannose
-
 ?
Glcalpha(1-3)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)[Manalpha(1-2)Manalpha(1-3)[Manalpha(1-2)Manalpha(1-6)]Manalpha(1-6)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O
-
 Homo sapiens Glcalpha(1-3)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)[Manalpha(1-2)Manalpha(1-3)[Manalpha(1-6)]Manalpha(1-6)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + D-mannose
-
 ?

Synonyms

Synonyms Comment Organism
class I alpha1,2-mannosidase
-
 Homo sapiens
EDEM1
-
 Homo sapiens
ER degradation enhancing alpha-mannosidase-like protein 1
-
 Homo sapiens
ER ManI
-
 Homo sapiens
ER mannosidase I
-
 Homo sapiens