Literature summary for 3.2.1.209 extracted from

Gonzalez, D.S.; Karaveg, K.; Vandersall-Nairn, A.S.; Lal, A.; Moremen, K.W.
Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis (1999), J. Biol. Chem., 274, 21375-21386.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
1-deoxymannojirimycin	10% residual activity at 0.0002 mM	Homo sapiens
EDTA	Ca2+ restores	Homo sapiens
EGTA	complete loss of acvtivity at 0.1 mM, Ca2+ restores	Homo sapiens
kifunensine	10% residual activity at 0.0002 mM	Homo sapiens
additional information	no inhibition by swainsonine	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	-	Homo sapiens	5783	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9UKM7	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAc + 4 H2O	-	Homo sapiens	(Man)5GlcNAc + 4 D-mannose	product is Man8GlcNAc	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7	-	-	Homo sapiens

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Release 2023.1 (January 2023)